Dual ultrasound-activatable nanodroplets for highly-penetrative and efficient ovarian cancer theranostics

Yang, Chao; Zhang, Yi; Luo, Yuanli; Qiao, Bin; Wang, Xingyue; Zhang, Liang; Chen, Qiaoqi; Cao, Yang; Wang, Zhigang; Ran, Haitao

doi:10.1039/c9tb02198a

Cited by 41 publications

(38 citation statements)

References 48 publications

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“…SDT ( Figure 4A). [37] Under US irradiation, the produced ADV phenomenon was shown to disrupt the adjacent vasculature system to reduce the resistance of drug diffusion, enabling nanosensitizers to penetrate deeper into the inner tissue.…”

Section: Organic-small-molecule Sonosensitizersmentioning

confidence: 99%

“…[16] Induction of cell death in vitro and distinct suppression of tumor growth in vivo adequately demonstrated Reproduced with permission. [37] Copyright 2019, Royal Society of Chemistry. B) Schematic representation of EXO-DVDMS.…”

Section: Organic-small-molecule Sonosensitizersmentioning

confidence: 99%

“…integrated the HMME sonosensitizer, and targeting folate (FA) molecules onto nanoliposomes with perfluoropentane (PFP) as the core to construct a kind of nanodroplet for targeted effect and acoustic droplet vaporization (ADV) conjointly enhanced SDT ( Figure A). [ 37 ] Under US irradiation, the produced ADV phenomenon was shown to disrupt the adjacent vasculature system to reduce the resistance of drug diffusion, enabling nanosensitizers to penetrate deeper into the inner tissue. The experimental results demonstrated that the FA‐H@NDs assisted by US irradiation generated excess ROS, resulting in high SDT efficiency.…”

Section: Sonosensitizersmentioning

confidence: 99%

Section: Sonosensitizersmentioning

confidence: 99%

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

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Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such as deeper penetration depth, absence of phototoxicity, and fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks to the facile engineering nature of nanotechnology, numerous novel nanoplatforms are being applied in this emerging field to tackle these intrinsic barriers and achieve continuous innovations. In particular, the combination of SDT with other treatment strategies has demonstrated a superior efficacy in improving anticancer activity relative to that of monotherapies alone. Therefore, it is necessary to summarize the nanomaterial-assisted combinational sonodynamic cancer therapy applications. Herein, the design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted. The ultimate goals are to stimulate the design of better-quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.

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Section: Organic-small-molecule Sonosensitizersmentioning

confidence: 99%

Section: Organic-small-molecule Sonosensitizersmentioning

confidence: 99%

Section: Sonosensitizersmentioning

confidence: 99%

Section: Sonosensitizersmentioning

confidence: 99%

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

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“…Additionally, the unwanted side effect could also be decreased through encapsulation of chemotherapy. It has been reported that perfluoropentane (PFP) owns an outstanding capacity of transforming from liquid phase to gas phase under irradiation, which could be applied as a novel ultrasound molecular probe, especially in ultrasonic imaging and treatment [30]. More importantly, the initial liquid phase enables PFP to be readily encapsulated in various materials [31].…”

Section: Introductionmentioning

confidence: 99%

Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer

et al. 2021

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The metastasis of breast cancer is believed to have a negative effect on its prognosis. Benefiting from the remarkable deep-penetrating and noninvasive characteristics, sonodynamic therapy (SDT) demonstrates a whole series of potential leading to cancer treatment. To relieve the limitation of monotherapy, a multifunctional nanoplatform has been explored to realize the synergistic treatment efficiency. Herein, we establish a novel multifunctional nano-system which encapsulates chlorin e6 (Ce6, for SDT), perfluoropentane (PFP, for ultrasound imaging), and docetaxel (DTX, for chemotherapy) in a well-designed PLGA core–shell structure. The synergistic Ce6/PFP/DTX/PLGA nanoparticles (CPDP NPs) featured with excellent biocompatibility and stability primarily enable its further application. Upon low-intensity focused ultrasound (LIFU) irradiation, the enhanced ultrasound imaging could be revealed both in vitro and in vivo. More importantly, combined with LIFU, the nanoparticles exhibit intriguing antitumor capability through Ce6-induced cytotoxic reactive oxygen species as well as DTX releasing to generate a concerted therapeutic efficiency. Furthermore, this treating strategy actives a strong anti-metastasis capability by which lung metastatic nodules have been significantly reduced. The results indicate that the SDT-oriented nanoplatform combined with chemotherapy could be provided as a promising approach in elevating effective synergistic therapy and suppressing lung metastasis of breast cancer.

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Multifunctional Porphyrin‐Based Sonosensitizers for Sonodynamic Therapy

Chen,

Zhou,

Cao

2024

Adv Funct Materials

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Sonodynamic therapy (SDT), as a promising non‐invasive therapeutic modality combining ultrasound (US) and sonosensitizers to produce cytotoxic reactive oxygen species (ROS) for treating deep‐seated tumors, has received increasing attention in recent years. Porphyrins are multifunctional organic materials, which can be excited both by light and US to produce ROS and possess various fascinating features, including controllable synthetic processes, excellent biodegradability, low cytotoxicity without light or US. Nevertheless, their poor water solubility, skin‐photosensitive toxicity, and insufficient target specificity hinder their clinical applications as sonosensitizer. Although the target specificity issue may be improved by using nanoparticle carriers, and the SDT efficacy can be enhanced by combining with other therapeutic modalities, such combination therapy makes it more confusing about the true mechanism of SDT. This review will focus on the following points: 1) Why are porphyrin‐based sonosensitizers considered the most promising sonosensitizer for clinical applications of SDT? 2) Recent progress in the development of multifunctional porphyrin‐based sonosensitizers. 3) What new insight has been gained on the mechanism of SDT in recent years? 4) The development trend of designing more efficient multifunctional porphyrin‐based sonosensitizers and existing challenges. Finally, future perspective of practical clinical applications of SDT based on multifunctional porphyrin‐based sonosensitizers will be discussed.

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Dual ultrasound-activatable nanodroplets for highly-penetrative and efficient ovarian cancer theranostics

Abstract: Upon US irradiation, FA-H@NDs can be activated for ADV-augmented deep penetration of sonosensitizers and SDT-induced therapy.

Cited by 41 publications

References 48 publications

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Low-Intensity Focused Ultrasound-Augmented Multifunctional Nanoparticles for Integrating Ultrasound Imaging and Synergistic Therapy of Metastatic Breast Cancer

Multifunctional Porphyrin‐Based Sonosensitizers for Sonodynamic Therapy

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