Dual-wavelength electrochemiluminescence biosensor based on a multifunctional Zr MOFs@PEI@AuAg nanocomposite with intramolecular self-enhancing effect for simultaneous detection of dual microRNAs

Electrostatic Interaction-Induced Aggregation-Induced Emission-Type AgAu Bimetallic Nanoclusters as a Highly Efficient Electrochemiluminescence Emitter for Ultrasensitive Detection of Glial Fibrillary Acidic Protein

“…Taking the ECL efficiency of ATT-AgAu BMNCs as a standard value of 1, the ECL efficiency (Φ ECL ) of CMCS@ATT-AgAu BMNCs was 18.4 times higher than that of ATT-AgAu BMNCs. Furthermore, as depicted in Figure C, the maximum PL emissions of CMCS@ATT-AgAu BMNCs (curve c) and ATT-AgAu BMNCs (curve d) were observed at 530 and 520 nm, respectively, and both the CMCS@ATT-AgAu BMNCs (curve a) and ATT-AgAu BMNCs (curve b) displayed obvious ECL emission peaks at 530 and 683 nm owing to the synergistic interaction between gold and silver atoms . The higher fluorescence intensity and ECL intensity of CMCS@ATT-AgAu BMNCs definitely proved its outstanding optical property.…”

“…Furthermore, as depicted in Figure 2C, the maximum PL emissions of CMCS@ATT-AgAu BMNCs (curve c) and ATT-AgAu BMNCs (curve d) were observed at 530 and 520 nm, respectively, and both the CMCS@ATT-AgAu BMNCs (curve a) and ATT-AgAu BMNCs (curve b) displayed obvious ECL emission peaks at 530 and 683 nm owing to the synergistic interaction between gold and silver atoms. 28 The higher fluorescence intensity and ECL intensity of CMCS@ATT-AgAu BMNCs definitely proved its outstanding optical property. Further, the three-dimensional (3D) ECL spectrum of CMCS@ATT-AgAu BMNCs (Figure 2D) visually exhibited the ECL emission of BMNCs.…”

Surface ligand-assisted synthesis and biomedical applications of metal–organic framework nanocomposites

“…3B). 63 PEI with a large amount of amine groups was modified to bind to the surface of Zr-MOFs and then linked with glutathione (GSH)-functionalized AuAg nanoparticles, realizing the assembly of the nanocomposites. Moreover, the covalent conjugation-driven assembly by car-boxyl groups and amino groups was also successfully demonstrated for the synthesis of Fe 3 O 4 @SiO 2 @MOF nanocomposites and graphene-MOF hybrids by using (3-aminopropyl) trimethoxysilane and graphene acid as the surface ligands, respectively, broadening the construction of MOF nanocomposites with different properties and functions.…”

A Controlled Release Aptasensor Utilizing AIE-Active MOFs as High-Efficiency ECL Nanoprobe for the Sensitive Detection of Adenosine Triphosphate

“…Previous studies have demonstrated the development of ECL emitters using Ru­(bpy) 3 2+ derivatives/porphyrin-based MOFs for the construction of biosensors capable of selective multiple-target analysis. − However, the presence of aggregation-caused quenching remains a challenge due to the agglomeration tendencies of the Ru (II) complex or porphyrin molecules, thereby limiting the ECL efficiency. Fortunately, the integration of aggregation-induced emission (AIE) molecules into MOFs has emerged as a promising research focus to enhance the ECL efficiency of emitters. − By effectively restricting the intramolecular motions of AIE luminogens (AIEgens), AIE ligand-based MOFs can achieve high emission efficiency through the coordination-induced ECL enhancement effect. , Currently, most reported AIE-active MOFs-based ECL systems necessitate the addition of the coreactants in the detection solution to attain strong ECL emission, − while the toxicity or instability of exogenous coreactants limits their further applications. In contrast, the exogenous coreactant-free ECL assay cannot only simplify the operation but also improve the reproducibility and accuracy of the ECL sensing platform.…”