Duck IFIT5 differentially regulates Tembusu virus replication and inhibits virus-triggered innate immune response

Wu, Xuedong; Liu, Ke; Jia, Renyong; Pan, Yu; Wang, Mingshu; Chen, Shun; Liu, Mafeng; Zhu, Dekang; Zhao, Xinxin; Wu, Ying; Yang, Qiao; Zhang, Shaqiu; Huang, Juan; Zhang, Ling; Liu, Yunya; Tian, Bin; Pan, Leichang; Yu, Yanling; Rehman, Mujeeb Ur; Yin, Zhongqiong; Jing, Bo; Cheng, Anchun

doi:10.1016/j.cyto.2020.155161

Cited by 11 publications

(6 citation statements)

References 49 publications

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“…A variety of avian viruses also upregulate IFIT5 expression. Avian-derived IFIT5 has a broad-spectrum antiviral effect ( Matulova et al, 2013 ; Liu et al, 2015 ; Wang et al, 2015 ; Li et al, 2020 ; Wu et al, 2020 ). Our study indicated that IFIT5 overexpression in DF-1 cells could inhibit ARV replication, whereas knockdown of endogenous IFIT5 expression in DF-1 cells by siRNA promoted ARV replication, indicating that IFIT5 genes are important ISGs for the host to resist ARV infection.…”

Section: Discussionmentioning

confidence: 99%

Screening of interferon-stimulated genes against avian reovirus infection and mechanistic exploration of the antiviral activity of IFIT5

Wang

Wan²,

Ren³

et al. 2022

Front. Microbiol.

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Section: Discussionmentioning

confidence: 99%

Screening of interferon-stimulated genes against avian reovirus infection and mechanistic exploration of the antiviral activity of IFIT5

Wang

Wan²,

Ren³

et al. 2022

Front. Microbiol.

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“…Recent experiments establish the antiviral function of these duck homologues. Overexpression of duck IFIT5 reduces viral titre at early timepoints but appears to inhibit innate immunity later (57). Duck OASL activates the OAS/RNaseL pathway (58).…”

Section: Discussionmentioning

confidence: 99%

Tissue Specific Transcriptome Changes Upon Influenza A Virus Replication in the Duck

et al. 2021

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Ducks are the natural host and reservoir of influenza A virus (IAV), and as such are permissive to viral replication while being unharmed by most strains. It is not known which mechanisms of viral control are globally regulated during infection, and which are specific to tissues during infection. Here we compare transcript expression from tissues from Pekin ducks infected with a recombinant H5N1 strain A/Vietnam 1203/04 (VN1203) or an H5N2 strain A/British Columbia 500/05 using RNA-sequencing analysis and aligning reads to the NCBI assembly ZJU1.0 of the domestic duck (Anas platyrhynchos) genome. Highly pathogenic VN1203 replicated in lungs and showed systemic dissemination, while BC500, like most low pathogenic strains, replicated in the intestines. VN1203 infection induced robust differential expression of genes all three days post infection, while BC500 induced the greatest number of differentially expressed genes on day 2 post infection. While there were many genes globally upregulated in response to either VN1203 or BC500, tissue specific gene expression differences were observed. Lungs of ducks infected with VN1203 and intestines of birds infected with BC500, tissues important in influenza replication, showed highest upregulation of pattern recognition receptors and interferon stimulated genes early in the response. These tissues also appear to have specific downregulation of inflammatory components, with downregulation of distinct sets of proinflammatory cytokines in lung, and downregulation of key components of leukocyte recruitment and complement pathways in intestine. Our results suggest that global and tissue specific regulation patterns help the duck control viral replication as well as limit some inflammatory responses in tissues involved in replication to avoid damage.

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“…Interferon induced RNA binding protein is involved in human innate immune response, and its abnormal expression can lead to related diseases, including lice infection [33]. It plays an important role in immunity and signal transduction [34,35]. Whether these genes act through m7G methylation and affect the prognosis of KIRC patients remains to be clari ed.…”

Section: Discussionmentioning

confidence: 99%

A Newly Defined m7G-Related Gene Signature for Overall Survival Prognosis of Kidney Renal Clear Cell Carcinoma

Yuan

Cheng

et al. 2022

Preprint

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Background: Kidney renal clear cell carcinoma (KIRC) is a highly malignant disease with unsatisfactory prognosis. In recent years, it has been reported that m7G methylation can regulate promoter sequence and induce gene expression or silencing so that affect tumor progression. However, the prognostic value of m7G-related genes in KIRC needs to be further clarified. Methods: In this paper, we downloaded the mRNA expression profile and corresponding clinical data of KIRC patients from the public database TCGA. The least absolute shrinkage and selection operator (LASSO) Cox regression model was utilized to construct a multigene signature in the TCGA cohort. A risk score model was established based on Kaplan-Meier and multivariate Cox regression analysis. Then, we performed functional enrichment analysis and immune infiltration analysis of differentially expressed genes between high-risk group and low-risk group.Result: 13 differentially expressed genes (DEGs) were found in normal and tumor tissues. Based on the median score calculated by the risk score formula from 29 m7G-related genes, 534 patients were divided into low-risk and high-risk subgroups, respectively. The survival probability of KIRC patients in the low-risk group was significantly better than that in the high-risk group(p<0.001). The tumor grade and risk level were independent predictors for OS in multivariate Cox regression analyses (HR> 1, P< 0.01). Receiver operating characteristic (ROC) curve analysis confirmed the signature's predictive capacity. Functional analysis revealed that human immunodeficiency was enriched, and immune status were different between two risk groups.Conclusion: A new m7G-related gene biomarker can be used to predict the prognosis of KIRC, which may be a therapeutic option for KIRC patients.

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Duck IFIT5 differentially regulates Tembusu virus replication and inhibits virus-triggered innate immune response

Cited by 11 publications

References 49 publications

Screening of interferon-stimulated genes against avian reovirus infection and mechanistic exploration of the antiviral activity of IFIT5

Screening of interferon-stimulated genes against avian reovirus infection and mechanistic exploration of the antiviral activity of IFIT5

Tissue Specific Transcriptome Changes Upon Influenza A Virus Replication in the Duck

A Newly Defined m7G-Related Gene Signature for Overall Survival Prognosis of Kidney Renal Clear Cell Carcinoma

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