Duck Liver–associated Outbreak of Campylobacteriosis among Humans, United Kingdom, 2011

Abid, Muhammad Abbas; Wimalarathna, Helen; Mills, Janette; Saldaña, Luisa; Pang, Winnie; Richardson, Judith; Maiden, Martin C. J.; McCarthy, Noel D.

doi:10.3201/eid1908.121535

Cited by 18 publications

(16 citation statements)

References 12 publications

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“…Several persons attending a wedding reception on 26 May 2012 became ill. An outbreak investigation identified chicken liver pâté as the suspected source of the infection. Several Campylobacter outbreaks associated with consumption of poultry liver pâté have been described especially in the UK (Abid et al., ; Edwards et al., ; Farmer et al., ; Forbes et al., ; Inns et al., ; Little et al., ; O'Leary et al., ; Wensley and Coole, ; Young et al., ) but also in other countries such as Australia (Merritt et al., ; Parry et al., ) and USA (Centers for Disease & Prevention, ).…”

Section: Introductionmentioning

confidence: 99%

Confirmation of a Campylobacteriosis Outbreak Associated with Chicken Liver Pâté Using PFGE and WGS

Lahti

Löfdahl

Ågren

et al. 2016

Zoonoses and Public Health

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In May 2012, an outbreak of campylobacteriosis occurred in southern Sweden at a wedding reception affecting 44 persons. A total of 17 cases were notified (13 were culture positive for Campylobacter spp.). Epidemiological investigation suspected chicken liver pâté as the source of infection. The liver pâté had been deliberately undercooked, lightly fried to keep the right texture and mixed with spices. Campylobacter isolates from six cases as well as three Campylobacter isolates from chicken flocks previously raised by the producer delivering the liver were subtyped using pulsed-field gel electrophoresis and whole-genome sequencing. Indistinguishable PFGE profiles were identified among five human and one chicken C. jejuni isolates as well among the two C. coli isolates, one from a human case and one from a chicken. WGS supported the PFGE findings; the six C. jejuni isolates belonged to one cluster. All these six isolates were of MLST type ST 50 (ST-CC 21). This study highlights the importance of a combination of strict biosecurity at the flock-level as well as adequate cooking of chicken liver to prevent transmission of Campylobacter to humans.

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Section: Introductionmentioning

confidence: 99%

Confirmation of a Campylobacteriosis Outbreak Associated with Chicken Liver Pâté Using PFGE and WGS

Lahti

Löfdahl

Ågren

et al. 2016

Zoonoses and Public Health

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show abstract

“…There is some evidence of an increased risk of Campylobacter infection in humans associated with ducks (10). A study in the United Kingdom found that duck meat was implicated in 2% of campylobacteriosis outbreaks (11), and a large outbreak of campylobacteriosis was derived from duck products in the United Kingdom (12). Previous surveys indicated high prevalences of Campylobacter in domestic ducks and duck meat (11,13).…”

mentioning

confidence: 99%

Antimicrobial Susceptibility Profiles and Molecular Typing of Campylobacter jejuni and Campylobacter coli Isolates from Ducks in South Korea

Wei

Cha

Kang

et al. 2014

Appl Environ Microbiol

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Campylobacter is a food-borne zoonotic pathogen that causes human gastroenteritis worldwide. Campylobacter bacteria are commensal in the intestines of many food production animals, including ducks and chickens. The objective of the study was to determine the prevalence of Campylobacter species in domestic ducks, and the agar dilution method was used to determine resistance of the isolates to eight antibiotics. In addition, multilocus sequence typing (MLST) was performed to determine the sequence types (STs) of selected Campylobacter isolates. Between May and September 2012, 58 duck farms were analyzed, and 56 (96.6%) were positive for Campylobacter. Among the isolates, 82.1% were Campylobacter jejuni, 16.1% were C. coli, and one was unidentified by PCR. Of the 46 C. jejuni isolates, 87.0%, 10.9%, and 21.7% were resistant to ciprofloxacin, erythromycin, and azithromycin, respectively. Among the C. coli isolates, all 9 strains were resistant to ampicillin, and 77.8% and 33.3% were resistant to ciprofloxacin and azithromycin, respectively. The majority of the Campylobacter isolates were classified as multidrug resistant. Twenty-eight STs were identified, including 20 STs for C. jejuni and 8 STs for C. coli. The most common clonal complexes in C. jejuni were the ST-21 complex and the ST-45 complex, while the ST-828 complex predominated in C. coli. The majority of isolates were of STs noted in ducks and humans from earlier studies, along with seven STs previously associated only with human disease. These STs overlapped between duck and human isolates, indicating that Campylobacter isolates from ducks should be considered potential sources of human infection.

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“…It is already apparent that studies of microbial pathogenicity at the molecular level have made substantial contributions to our understanding of the epidemiology, clinical manifestations, diagnosis, treatment, and immunoprophylaxis of infectious diseases. Infectious disease epidemiology hinges on a clear definition of the clinical problem under study and, moreover, precise identification of the etiologic agent [3][4][5][6]. Molecular techniques provide for the sensitive and specific detection of putative pathogens and supply a means for establishing relationships among multiple isolates of the same species.…”

Section: Pathogen Detection Pathogen Discovery and Genomic Profilingmentioning

confidence: 99%

“…Molecular techniques have been used in other epidemiologic investigations to study transmission mechanisms and the role of avirulent microbial variants in the spread of disease [3][4][5][6][7]. Molecular strain typing data some-times provide the only clue that a group of cases are related, that is, that an outbreak of disease has occurred.…”

Section: Pathogen Detection Pathogen Discovery and Genomic Profilingmentioning

confidence: 99%

“…PCR, reverse transcription PCR (RT-PCR), real-time RT-PCR and nucleic acid amplification tests (ΝΑΤ) are some of the molecular methods used for identification of viruses, depending on the requirements. Circulation of the virus in a given area usually precedes the onset of an outbreak by a year or more, and the detection of a specific viral strain in space and time helps the instigation of an efficient infection surveillance system [5].…”

Section: Molecular Epidemiology Infectious Diseasesmentioning

confidence: 99%

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Role of Molecular Epidemiology in Infectious Disease Surveillance

Gupte

Ravikant

Kaur³

2016

JHVRV

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Molecular epidemiology is progressively a vast area of research and now molecular biology techniques have become increasingly integrated into the practice of infectious disease epidemiology. By definition molecular epidemiology is molecular strain-typing or we can say fingerprinting techniques regardless any epidemiologic application. Molecular is basically the use of the techniques of molecular biology and the epidemiology is the study of the distribution and determinants of disease occurrence in human populations. The benefits and challenges of applying these techniques to disease and their affected host is the core which gets served by molecular epidemiologist.

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Duck Liver–associated Outbreak of Campylobacteriosis among Humans, United Kingdom, 2011

Cited by 18 publications

References 12 publications

Confirmation of a Campylobacteriosis Outbreak Associated with Chicken Liver Pâté Using PFGE and WGS

Confirmation of a Campylobacteriosis Outbreak Associated with Chicken Liver Pâté Using PFGE and WGS

Antimicrobial Susceptibility Profiles and Molecular Typing of Campylobacter jejuni and Campylobacter coli Isolates from Ducks in South Korea

Role of Molecular Epidemiology in Infectious Disease Surveillance

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