Ductal carcinoma in situ of the breast: Results of treatment by conservative surgery and definitive irradiation

Long term follow-up of women with ductal carcinoma in situ treated with breast-conserving surgery

“…16 In re-ported retrospective series with at least 60 months of follow-up, local recurrence rates range from 6% to 63% for excision alone 40 -47 and from 6% to 21% for excision followed by adjuvant breast irradiation. 18,32,33,[47][48][49][50][51][52] The current study reports our findings regarding the influence of age, radiation therapy, and various pathologic parameters on recurrence rates.…”

“…16,40 -47 For women treated by excision and radiation therapy, 10 studies with follow-up of at least 5 years (range, 61-132 months) describe crude recurrence rates ranging from 6% to 21%, with a total of 151 (14%) of 1116 patients having local relapse. 16,18,32,33,[47][48][49][50][51][52] A criticism of the current study is the large number of specimens with microscopically indeterminate margins. Unfortunately, until the mid 1980s, the inking of margins was an uncommonly used technique, and the largest long term studies that have reported on DCIS from this time period suffer from the same weakness.…”

Standards for diagnosis and management of ductal carcinoma in situ (DCIS) of the breast. American College of Radiology. American College of Surgeons. College of American Pathologists. Society of Surgical Oncology

“…Most breast tumor recurrences in patients undergoing conservative surgery and radiation for DCIS occur near the primary tumor, and approximately 50% are invasive cancers 6–8,12,14,16–20 . Invasive recurrences appear at later intervals (5 years) than do noninvasive recurrences (4 years) and may occur in a separate quadrant 9,17 .…”

“…Invasive recurrences appear at later intervals (5 years) than do noninvasive recurrences (4 years) and may occur in a separate quadrant 9,17 . Nearly all patients who develop a noninvasive recurrence are salvaged with mastectomy, and approximately 75% of those with an invasive recurrence are salvaged 7,8,12,16,18–21 …”