Local Tumor Recurrence following Breast-Conservation Therapy: Correlation of Histopathologic Findings with Detection Method and Mammographic Findings

Abstract

In local recurrence after breast-conservation therapy for DCIS, histopathologic findings, detection method, and mammographic findings are usually similar. Histopathologic findings of primary invasive breast carcinoma and local recurrence are usually similar, but the detection method and mammographic findings vary. This is relevant to the interpretation of new clinical or mammographic findings following lumpectomy.

Computed tomography in suspected local breast cancer recurrence

“…However, the optimal timing and frequency of follow-up mammography have yet to be established [13]. Finally, quality control and close mammographic surveillance help detect mammographic changes which can herald local recurrence [14].…”

Mammographic features of local recurrence after conservative surgery and radiation therapy: comparison with that of the primary tumor

“…In our series, 76% (31/41) of the recurrences occurred in the same quadrant as the primary tumor. This rate has been reported as 55%, 70%, and 80% by OREL et al (17), GIESS et al (8), and LIBERMAN et al (14), respectively. Local recurrences that occur late and not at the site of the original primary tumor probably represent new breast cancers rather than failures of definitive irradiation for the original breast cancer (20,28).…”

Relation between the method of detection of initial breast carcinoma and the method of detection of subsequent ipsilateral local recurrence and contralateral breast carcinoma

“…The detection method and mammographic appearance in a primary tumor are not always correlated with that of the locally recurrent breast carcinoma after breast conservation therapy, 21 and contralateral breast tumors often have mammographic findings that are different from those of the first carcinoma. 22 A primary breast carcinoma that was detected by mammography only can recur as a tumor that is not able to be detected mammographically and vice versa.…”