Duodenal Absorption and Tissue Utilization of Dietary Heme and Nonheme Iron Differ in Rats

Cao, Chang; Thomas, Carrie; Insogna, Karl L.; O’Brien, Kimberly

doi:10.3945/jn.114.197939

Cited by 12 publications

(14 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Proper heme levels are also crucial for normal fetal development, as defects can lead to limb deformities in addition to abnormal erythropoiesis (Keel et al, 2008). Not surprisingly then, increased circulatory hepcidin can have systemic effects; for example, decreasing heme-and nonhemeiron absorption to the duodenum (Cao et al, 2014). In the present case, the levels of hepcidin in the Nan/+ mouse are high enough to exert a physiological effect (Nemeth et al, 2004b).…”

Section: Discussionmentioning

confidence: 65%

Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development

Planutis

Xue

Trainor³

et al. 2017

Development

View full text Add to dashboard Cite

Transcription factor control of cell-specific downstream targets can be significantly altered when the controlling factor is mutated. We show that the semi-dominant neonatal anemia (Nan) mutation in the EKLF/ KLF1 transcription factor leads to ectopic expression of proteins that are not normally expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in the adult and alter correct development in the early embryo. Even when expressed as a heterozygote, the Nan-EKLF protein accomplishes this by direct binding and aberrant activation of genes encoding secreted factors that exert a negative effect on erythropoiesis and iron use. Our data form the basis for a novel mechanism of physiological deficiency that is relevant to human dyserythropoietic anemia and likely other disease states.

show abstract

Section: Discussionmentioning

confidence: 65%

Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development

Planutis

Xue

Trainor³

et al. 2017

Development

View full text Add to dashboard Cite

show abstract

“…Iron utilization and bioavailability from the heme iron source was substantially higher than that observed for ferrous sulfate (nonheme iron) in both the pregnant and nonpregnant individuals (12)(13)(14). Furthermore, data from animal studies showed considerable differences in tissue deposition of the absorbed heme and nonheme iron tracers, suggesting that some heme may be exported into the circulation in a form different from that of nonheme iron (9). Data also support that there may be differential use of iron from heme and nonheme sources during pregnancy (65).…”

Section: Discussionmentioning

confidence: 92%

“…In humans, iron status is primarily regulated by the intestinal iron absorption of consumed external iron (8,9), as discussed elsewhere in these proceedings (10). Dietary iron is present in 2 forms: heme iron (animal flesh products) and nonheme iron (plants, some animal products, and supplements).…”

Section: Introductionmentioning

confidence: 99%

Dietary iron intake, iron status, and gestational diabetes

Zhang

Rawal

2017

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

Pregnant women are particularly vulnerable to iron deficiency and related adverse pregnancy outcomes and, as such, are routinely recommended for iron supplementation. Emerging evidence from both animal and population-based studies, however, has raised potential concerns because significant associations have been observed between greater iron stores and disturbances in glucose metabolism, including increased risk of type 2 diabetes among nonpregnant individuals. Yet, the evidence is uncertain regarding the role of iron in the development of gestational diabetes mellitus (GDM), a common pregnancy complication which has short-term and long-term adverse health ramifications for both women and their children. In this review, we critically and systematically evaluate available data examining the risk of GDM associated with dietary iron, iron supplementation, and iron status as measured by blood concentrations of several indicators. We also discuss major methodologic concerns regarding the available epidemiologic studies on iron and GDM.Am J Clin Nutr 2017;106(Suppl):1672S-80S.

show abstract

“…A diet generally contains heme iron (present in animal foods) with high bioavailability (15-35%) and non-heme iron (especially present in plantbased foods) with 1-20% bioavailability. 14 , 15 Heme iron generally constitutes only about 15% of the total dietary iron intake. 14 , 15 Two previous studies among blood donors did not find associations between intake of iron-rich food items and iron stores or Hb levels, 16 , 17 while one study among blood donors found mainly meat intake to be associated with iron stores.…”

Section: Introductionmentioning

confidence: 99%

Dietary intake of heme iron is associated with ferritin and hemoglobin levels in Dutch blood donors: results from Donor InSight

et al. 2019

View full text Add to dashboard Cite

Whole blood donors, especially frequently donating donors, have a risk of iron deficiency and low hemoglobin levels, which may affect their health and eligibility to donate. Lifestyle behaviors, such as dietary iron intake and physical activity, may influence iron stores and thereby hemoglobin levels. We aimed to investigate whether dietary iron intake and questionnaire-based moderate-to-vigorous physical activity were associated with hemoglobin levels, and whether ferritin levels mediated these associations. In Donor InSight-III, a Dutch cohort study of blood and plasma donors, data on heme and non-heme iron intake (mg/day), moderate-to-vigorous physical activity (10 minutes/day), hemoglobin levels (mmol/L) and ferritin levels (μg/L) were available in 2,323 donors (1,074 male). Donors with higher heme iron intakes (regression coefficients (β) in men and women: 0.160 and 0.065 mmol/L higher hemoglobin per 1 mg of heme iron, respectively) and lower non-heme iron intakes (β: -0.014 and -0.017, respectively) had higher hemoglobin levels, adjusted for relevant confounders. Ferritin levels mediated these associations (indirect effect (95% confidence interval) in men and women respectively: 0.074 (0.045; 0.111) and 0.061 (0.030; 0.096) for heme and -0.003 (-0.008;0.001) and -0.008 (-0.013;-0.003) for non-heme). Moderate-to-vigorous physical activity was negatively associated with hemoglobin levels in men only (β: -0.005), but not mediated by ferritin levels. In conclusion, higher heme and lower non-heme iron intake were associated with higher hemoglobin levels in donors, via higher ferritin levels. This indicates that donors with high heme iron intake may be more capable of maintaining iron stores to recover hemoglobin levels after blood donation.

show abstract

Duodenal Absorption and Tissue Utilization of Dietary Heme and Nonheme Iron Differ in Rats

Cited by 12 publications

References 52 publications

Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development

Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development

Dietary iron intake, iron status, and gestational diabetes

Dietary intake of heme iron is associated with ferritin and hemoglobin levels in Dutch blood donors: results from Donor InSight

Contact Info

Product

Resources

About