Duodenal hemangiopericytoma

Ferrozzi, F; S, Armaroli; Pedrazzini, M; Tognini, Giuseppe; Pavone, Paolo

doi:10.1016/s0899-7071(01)00258-3

Cited by 2 publications

(4 citation statements)

References 11 publications

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“…reported that duodenal GIST are occasionally accompanied by dilated vessels and/or hemangioma‐like vascular proliferation; in their cases, however, the tumors were composed of spindle cells or epithelioid cells, and the vessels did not have the HPC‐like staghorn configuration 12 . Thus far, several GI tract tumors have been reported under the diagnostic label of ‘hemangiopericytoma’, but immunohistochemical staining for KIT and mutation analysis of the KIT and PDGFRA genes were not performed in these cases 13,14 …”

Section: Discussionmentioning

confidence: 95%

“…12 Thus far, several GI tract tumors have been reported under the diagnostic label of 'hemangiopericytoma', but immunohistochemical staining for KIT and mutation analysis of the KIT and PDGFRA genes were not performed in these cases. 13,14 As mentioned earlier, HPC is characterized by the proliferation of undifferentiated, round to fusiform tumor cells around branching vessels that have a staghorn configuration. Silver staining shows that each tumor cell is surrounded by reticulin fibers.…”

Section: Discussionmentioning

confidence: 99%

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Gastrointestinal stromal tumor in the duodenum exhibiting hemangiopericytoma‐like histological pattern

Takahashi

Shimizu

Sakurai

et al. 2009

Pathology International

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Reported herein is a gastrointestinal stromal tumor (GIST) that exhibited a hemangiopericytoma (HPC)-like histological pattern. Such a morphological variant of GIST has not been described previously. A 57-year-old woman presented with bloody stools. On upper digestive tract endoscopy a submucosal tumor of diameter 2 cm was detected at the duodenal bulb, and enucleated. Grossly, the tumor was well-circumscribed, grayish to whitish, and solid, and its central portion was ulcerated. Histology indicated round to fusiform tumor cells that had proliferated around branching vessels that had a staghorn configuration. Immunohistochemistry showed that the tumor cells were diffusely positive for vimentin and KIT; partially positive for CD34 and muscle actin; and negative for alpha-smooth muscle actin. On mutation analysis a 42 bp deletion was found from codons 560 to 573 of exon 11 of the KIT gene, which is a mutational hot spot of GIST. In diagnosis of gastrointestinal tract tumors with an HPC-like histological pattern, pathologists should consider the possibility of GIST.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Gastrointestinal stromal tumor in the duodenum exhibiting hemangiopericytoma‐like histological pattern

Takahashi

Shimizu

Sakurai

et al. 2009

Pathology International

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“…[4][5][6] In rare cases, hemangiopericytoma may arise from the gastrointestinal tract, meninges, or parotid gland. [7][8][9] Although meningeal hemangiopericytoma (M-HPC) was initially believed to be a meningioma variant (angioblastic meningioma, hemangiopericytic type), it is now recognized as a distinct pathologic entity with different clinical behavior, immunohistochemical characteristics, and ultrastructural features from those of meningioma. [9][10][11] In the present case, the characteristics of the multiple metastases of hemangiopericytoma were extreme hypervascularity in the solid portion and sharp margins as depicted by US, CT, and MRI.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8][9] According to a review of the literature, whether primary or metastatic, hemangiopericytoma displays as a well-defined mass containing solid and cystic components and with extreme hypervascularity in the solid component. [4][5][6][7][8][9] Meningeal hemangiopericytoma is aggressive and tends to recur even after gross total resection. 9,11 Late extraneural metastases after a prolonged disease-free interval are common in the course of meningeal hemangiopericytoma.…”

Section: Discussionmentioning

confidence: 99%

Multiple metastases from a meningeal hemangiopericytoma associated with severe hypoglycemia

et al. 2005

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Hemangiopericytomas are rare vascular tumors that may be associated with profound hypoglycemia. We present correlative imaging findings for a 57-year-old woman who had multiple abdominal and muscular metastases with severe hypoglycemia 11 years after resection of meningeal hemangiopericytoma. The metastases were well-defined masses containing solid and cystic components, and they were extremely hypervascular in the solid component. Those characteristics on imaging associated with hypoglycemia and the past history of meningeal hemangiopericytoma may suggest the diagnosis and be helpful in differentiating the mass from other vascular tumors. Color and power Doppler ultrasound may play a valuable role in characterizing and diagnosing metastasis from hemangiopericytoma. A delay of several years between diagnosis of the primary hemangiopericytoma and the manifestation of metastasis appears to be a special feature of hemangiopericytoma.

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Duodenal hemangiopericytoma

Cited by 2 publications

References 11 publications

Gastrointestinal stromal tumor in the duodenum exhibiting hemangiopericytoma‐like histological pattern

Gastrointestinal stromal tumor in the duodenum exhibiting hemangiopericytoma‐like histological pattern

Multiple metastases from a meningeal hemangiopericytoma associated with severe hypoglycemia

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