Duodenal Infusion of Donor Feces for Recurrent<i>Clostridium difficile</i>

Nood, Els van; Vrieze, Anne; Nieuwdorp, Max; Fuentes, Susana; Zoetendal, Erwin G.; Vos, Willem M. de; Visser, Caroline E.; Kuijper, Ed J.; Speelman, Peter; Keller, Josbert J.

doi:10.1056/nejmoa1205037

Cited by 3,242 publications

(2,510 citation statements)

References 32 publications

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“…8 First, a screening program that minimizes the risk of transferring infectious and non-infectious diseases must be implemented. Detailed screening protocols have been published, 7 , 9-11 but the work required for their implementation is extensive; moreover, despite a scientific consensus for this vigorous screening, 12 , 13 the evidence supporting the screening protocols remains low. Second, as FMT gains momentum, an inherent need for recruiting enough potential feces donors evolves.…”

Section: Introductionmentioning

confidence: 99%

Recruitment of feces donors among blood donors: Results from an observational cohort study

et al. 2018

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As the use of fecal microbiota transplantation (FMT) has gained momentum, an increasing need for continuous access to healthy feces donors has developed. Blood donors constitute a healthy subset of the general population and may serve as an appropriate group for recruitment. In this study, we investigated the suitability of blood donors as feces donors. In a prospective cohort study, we recruited blood donors onsite at a public Danish blood bank. Following their consent, the blood donors underwent a stepwise screening process: First, blood donors completed an electronic pre-screening questionnaire to rule out predisposing risk factors. Second, eligible blood donors had blood and fecal samples examined. Of 155 blood donors asked to participate, 137 (88%) completed the electronic pre-screening questionnaire, 16 declined, and 2 were excluded. Of the 137 donors who completed the questionnaire, 79 (58%) were excluded mainly due to having an allergy, being overweight, or presenting gastrointestinal complaints. Among the remaining 58 (37%) donors, complete blood and feces screenings were obtained from 46 (79%). Of these 46 donors, 15 (33%) were excluded primarily due to abnormal blood results or the presence of apathogenic intestinal parasites. Overall, 31 (20%; 95% confidence interval 14–27%) of the 155 blood donors qualified as feces donors. In conclusion, blood donors constitute a suitable and motivated population for a continuous recruitment of voluntary feces donors. We found that a stepwise recruitment procedure was feasible and that 20% of the blood donors were eligible for feces donation.

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Section: Introductionmentioning

confidence: 99%

Recruitment of feces donors among blood donors: Results from an observational cohort study

et al. 2018

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“…The concentrations of seven SCFAs in the fecal samples were measured by gas chromatography‐mass spectrometry 8. The transplant‐microbial solution was prepared from the donor's feces,1 and then about 400 mL was infused into the recipient by colonoscopy. The solution was infused into the cecum to the ascending colon only once.…”

Section: Differential Diagnosis/investigation Of Therapymentioning

confidence: 99%

“…Fecal microbiota transplantation (FMT) therapy for patients with Clostridium difficile infection colitis has been found to have surprising efficacy 1. Dysbiosis of the intestinal flora is a problem and possible cause in diseases such as colorectal carcinoma, hepatocellular carcinoma, diabetes mellitus, obesity, and NASH 2, 3, 4, 5.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of fecal microbiota transplantation in a patient with chronic intractable constipation

Ohara

Suzutani

2018

Clinical Case Reports

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“…Clostridium difficile decreased from initial 4% to 0.2% after FMT. The low microbiota diversity in the patients increased to the diversity of the donors within 2 weeks (van Nood et al ., 2013; Fuentes et al ., 2014). A recent trial reproduced an 84% cure rate with faecal transplantation given as enema to 232 Canadian CDI patients, who were after intensive antibiotic pretreatment randomized to either fresh or frozen stool preparations, without difference in cure rate (Lee et al ., 2016).…”

Section: Introducing Beneficial Bacteria Into the Gut Microbiomementioning

confidence: 99%

Biome engineering‐2020

Brüssow

2016

Microbial Biotechnology

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SummaryThe gut microbiome research is going from a descriptive into an intervention phase. To optimize beneficial microbe–host interaction, we need to understand how to steer the system by modulating the nutrient input with which the system is literally fed (e.g. diets, fibres, prebiotics, human milk oligosaccharides), and we must learn how to modulate the composition of the gut microbiota by adding beneficial microbes (e.g. probiotics, faecal transplants) and by eliminating disturbing microbial members using, for example, bacteriophages in this highly complex ecosystem. The current status of the field is reviewed together with an outlook what might be expected until 2020, highlighting obstacles to progress and possible solutions to these problems.

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Duodenal Infusion of Donor Feces for RecurrentClostridium difficile

Cited by 3,242 publications

References 32 publications

Recruitment of feces donors among blood donors: Results from an observational cohort study

Recruitment of feces donors among blood donors: Results from an observational cohort study

Efficacy of fecal microbiota transplantation in a patient with chronic intractable constipation

Biome engineering‐2020

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