Duodenogastric reflux and gastric stump carcinoma

Kondo, Ken

doi:10.1007/s101200200002

Cited by 84 publications

(57 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thirteen patients (6.4 %) in our study group underwent a subtotal gastrectomy rather than a total gastrectomy as treatment of their remnant gastric cancer. A gastrectomy, whether indicated for a benign or malignant process, alters the environment of the remnant stomach in such a way that novel neoplastic processes are more likely to arise [25,26]. In addition, genetic factors such as p53 have also been suggested as etiological factors for carcinogenesis in the context of a gastrectomy for carcinoma [27,28].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for complications during surgical treatment of remnant gastric cancer

et al. 2014

View full text Add to dashboard Cite

Background Surgical treatment for remnant gastric cancer is related to high mortality and morbidity. The aim of this study was to identify risk factors that predispose to postoperative complications after gastrectomy for remnant gastric cancer. Methods A total of 210 patients who underwent a gastrectomy for remnant gastric cancer between January 1998 and December 2012 were retrospectively analyzed. Surgical complications were reviewed and graded using the Clavien-Dindo classification. Univariate and multivariate analysis was performed to identify the risk factors for development of complications. Results The incidence of postoperative complications was 46 % (96/210), and major complications occurred in 14 % (30/210). The operation-related mortality rate was 1.0 %. Multivariate analysis revealed that only a BMI C25 (P = 0.001) and blood transfusion (P \ 0.001) were significant independent risk factors for major complication. Indication for the initial gastrectomy and previous anastomosis type were not related to the development of surgical complications. Conclusions Although surgery for remnant gastric cancer is a complex procedure because of the previous operation, factors related to the previous operation do not affect the development of postoperative complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Risk factors for complications during surgical treatment of remnant gastric cancer

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In particular, rat models without the use of the carcinogen N-methyl-N 0 -nitro-N-nitrosoguanidine showed adenocarcinoma in the remnant stomach that was related to the severity of the duodenogastric reflux. A relationship between gastritis cystica polyposa and gastric-type adenocarcinoma has been suggested [38].…”

Section: Molecular Carcinogenesis Of Rgcmentioning

confidence: 99%

Does remnant gastric cancer really differ from primary gastric cancer? A systematic review of the literature by the Task Force of Japanese Gastric Cancer Association

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In the remnant stomach of rats after gastrectomy, bile acids are implicated in gastric cancer due to duodenogastric reflux [30]. In humans, duodenogastric reflux is also implicated in gastric stump carcinoma [31].…”

Section: Gastric Cancermentioning

confidence: 99%

Field defects in progression to gastrointestinal tract cancers

Bernstein

Payne

et al. 2008

Cancer Letters

View full text Add to dashboard Cite

A field of defective tissue may represent a pre-malignant stage in progression to many cancers. However, field defects are often overlooked in studies of cancer progression through assuming tissue at some distance from the cancer is normal. We indicate, however, the generality of field defects in gastrointestinal cancers, including cancers of the oropharynx, esophagus, stomach, bile duct, pancreas, small intestine and colon/rectum. Common features of these field defects are reduced apoptosis competence, aberrant proliferation and genomic instability. These features are often associated with high bile acid exposure and may explain the association of dietary-related factors with cancer progression.

show abstract

Duodenogastric reflux and gastric stump carcinoma

Cited by 84 publications

References 59 publications

Risk factors for complications during surgical treatment of remnant gastric cancer

Risk factors for complications during surgical treatment of remnant gastric cancer

Does remnant gastric cancer really differ from primary gastric cancer? A systematic review of the literature by the Task Force of Japanese Gastric Cancer Association

Field defects in progression to gastrointestinal tract cancers

Contact Info

Product

Resources

About