Dupuytren’s disease: where do we stand?

Grazina, Rita; Teixeira, Sérgio; Ramos, Renato T.; Sousa, Henrique; Ferreira, Andreia; Lemos, Rui

doi:10.1302/2058-5241.4.180021

Cited by 32 publications

(31 citation statements)

References 47 publications

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“…Inhibition of MLCK and CaM by specific inhibitors (ML-7 and W-7, respectively), prevents the migration of myofibroblasts induced by cardiotrophin-1 participating in the repair of scars after infarction [68]. Dupuytren's disease is an idiopathic fibroproliferative condition characterized by the formation of nodular lesions in the palmar fascia where the accumulation of fibroblasts and highly contractile myofibroblasts severely alters the function of the hands (reviewed in [102]). The CaM antagonist fluphenazine inhibited the migration of fibroblasts isolated from the collagen lattice of pathological lesions of patients with Dupuytren's disease, and this was attributed to MLCK inhibition [62].…”

Section: Cam and Cytoskeleton Dynamicsmentioning

confidence: 99%

The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis

Villalobo

Berchtold

2020

IJMS

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Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon binding to target proteins transduces signals encoded by global or subcellular-specific changes of Ca2+ concentration within the cell. The Ca2+/CaM complex as well as Ca2+-free CaM modulate the activity of a vast number of enzymes, channels, signaling, adaptor and structural proteins, and hence the functionality of implicated signaling pathways, which control multiple cellular functions. A basic and important cellular function controlled by CaM in various ways is cell motility. Here we discuss the role of CaM-dependent systems involved in cell migration, tumor cell invasiveness, and metastasis development. Emphasis is given to phosphorylation/dephosphorylation events catalyzed by myosin light-chain kinase, CaM-dependent kinase-II, as well as other CaM-dependent kinases, and the CaM-dependent phosphatase calcineurin. In addition, the role of the CaM-regulated small GTPases Rac1 and Cdc42 (cell division cycle protein 42) as well as CaM-binding adaptor/scaffold proteins such as Grb7 (growth factor receptor bound protein 7), IQGAP (IQ motif containing GTPase activating protein) and AKAP12 (A kinase anchoring protein 12) will be reviewed. CaM-regulated mechanisms in cancer cells responsible for their greater migratory capacity compared to non-malignant cells, invasion of adjacent normal tissues and their systemic dissemination will be discussed, including closely linked processes such as the epithelial–mesenchymal transition and the activation of metalloproteases. This review covers as well the role of CaM in establishing metastatic foci in distant organs. Finally, the use of CaM antagonists and other blocking techniques to downregulate CaM-dependent systems aimed at preventing cancer cell invasiveness and metastasis development will be outlined.

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Section: Cam and Cytoskeleton Dynamicsmentioning

confidence: 99%

The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis

Villalobo

Berchtold

2020

IJMS

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“…Furthermore, according to the subgroup’s analysis of the underlying diseases, the highest prevalence of the disease, after diabetic patients, is related to alcoholic patients (24%). Various studies reveal that the prevalence of Dupuytren in alcoholics is higher than the general population; however, the cause is still not clear [ 79 , 80 ]. Alcohol consumption and its misuse as a social harm have complex interconnected economic, social and cultural causes and have serious safety and health consequences for the society.…”

Section: Discussionmentioning

confidence: 99%

The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis

et al. 2020

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Background The Dupuytren disease is a benign fibroproliferative disorder that leads to the formation of the collagen knots and fibres in the palmar fascia. The previous studies reveal different levels of Dupuytren’s prevalence worldwide; hence, this study uses meta-analysis to approximate the prevalence of Dupuytren globally. Methods In this study, systematic review and meta-analysis have been conducted on the previous studies focused on the prevalence of the Dupuytren disease. The search keywords were Prevalence, Prevalent, Epidemiology, Dupuytren Contracture, Dupuytren and Incidence. Subsequently, SID, MagIran, ScienceDirect, Embase, Scopus, PubMed and Web of Science databases and Google Scholar search engine were searched without a lower time limit and until June 2020. In order to analyse reliable studies, the stochastic effects model was used and the I2 index was applied to test the heterogeneity of the selected studies. Data analysis was performed within the Comprehensive Meta-Analysis Software version 2.0. Results By evaluating 85 studies (10 in Asia, 56 in Europe, 2 in Africa and 17 studies in America) with a total sample size of 6628506 individuals, the prevalence of Dupuytren disease in the world is found as 8.2% (95% CI 5.7–11.7%). The highest prevalence rate is reported in Africa with 17.2% (95% CI 13–22.3%). According to the subgroup analysis, in terms of underlying diseases, the highest prevalence was obtained in patients with type 1 diabetes with 34.1% (95% CI 25–44.6%). The results of meta-regression revealed a decreasing trend in the prevalence of Dupuytren disease by increasing the sample size and the research year (P < 0.05). Conclusion The results of this study show that the prevalence of Dupuytren disease is particularly higher in alcoholic patients with diabetes. Therefore, the officials of the World Health Organization should design measures for the prevention and treatment of this disease.

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“…Verglichen mit den hohen Rekurrenzraten der NF sind diese bei der limitierten Fasziektomie (lF) sowie bei der Dermofasziektomie (DF) deutlich niedriger (lF mit 6-21 %, DF 0 %) [12]. Durch ihre deutlich höhere Invasivität mit der Notwendigkeit eines Skingrafts bei der DF sollte diese Op tion jedoch eher erst im fortgeschrittenen Stadium erwo gen werden [5].…”

Section: Limited-joint-mobility-syndromunclassified

Rheumatische Erkrankungen bei Diabetes mellitus

Wellstein

Baerwald

2021

Diabetes aktuell

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ZUSAMMENFASSUNGErkrankungen des Bewegungsapparats gehören zu den häufigsten Vorstellungsgründen in einer Hausarztpraxis. Wichtig ist in dem Zusammenhang ein frühzeitiges Erkennen und präventives Vorgehen zum Erhalt der Lebensqualität und Vermeidung von Morbidität. Ein Diabetes mellitus stellt für einige Erkrankungen einen wichtigen prädiktiven sowie verlaufsbestimmenden Faktor dar. Dieser Artikel zielt darauf ab, Ihnen das Wissen über die Erkrankungen und ihre Entstehung, praktische diagnostische Möglichkeiten sowie Therapieoptionen zu vermitteln und soll damit eine individuelle Behandlungsstrategie ermöglichen.

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Dupuytren’s disease: where do we stand?

Cited by 32 publications

References 47 publications

The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis

The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis

The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis

Rheumatische Erkrankungen bei Diabetes mellitus

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