The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis

Abstract

Background The Dupuytren disease is a benign fibroproliferative disorder that leads to the formation of the collagen knots and fibres in the palmar fascia. The previous studies reveal different levels of Dupuytren’s prevalence worldwide; hence, this study uses meta-analysis to approximate the prevalence of Dupuytren globally. Methods In this study, systematic review and meta-analysis have been conducted on the previous studies focused on the prevalence of the Dupuytren disease. The search keywords were Prevalence, Prevalent, Epidemiology, Dupuytren Contracture, Dupuytren and Incidence. Subsequently, SID, MagIran, ScienceDirect, Embase, Scopus, PubMed and Web of Science databases and Google Scholar search engine were searched without a lower time limit and until June 2020. In order to analyse reliable studies, the stochastic effects model was used and the I2 index was applied to test the heterogeneity of the selected studies. Data analysis was performed within the Comprehensive Meta-Analysis Software version 2.0. Results By evaluating 85 studies (10 in Asia, 56 in Europe, 2 in Africa and 17 studies in America) with a total sample size of 6628506 individuals, the prevalence of Dupuytren disease in the world is found as 8.2% (95% CI 5.7–11.7%). The highest prevalence rate is reported in Africa with 17.2% (95% CI 13–22.3%). According to the subgroup analysis, in terms of underlying diseases, the highest prevalence was obtained in patients with type 1 diabetes with 34.1% (95% CI 25–44.6%). The results of meta-regression revealed a decreasing trend in the prevalence of Dupuytren disease by increasing the sample size and the research year (P < 0.05). Conclusion The results of this study show that the prevalence of Dupuytren disease is particularly higher in alcoholic patients with diabetes. Therefore, the officials of the World Health Organization should design measures for the prevention and treatment of this disease.

An Overview of Dupuytren’s Disease for Perioperative Nurses

“…The disease may affect descendants of northern European ancestry more than other groups; however, results of a 2020 study that included a genetic risk score showed no genetic evidence of a Viking origin for the disease 3 . Results of a literature review of 85 studies on the condition show a current worldwide prevalence rate of 8.2% (95% confidence interval [CI] = 5.7 to 11.7) with the highest prevalence in Africa at 17.2% (95% CI = 13 to 22.3) 4 . In 1831, Baron Guillaume Dupuytren was the first person to formally present a lecture to the medical community on permanent contractions of the flexed fingers and publish his findings; 5 the disease now bears his name 1 .…”

“…3 Results of a literature review of 85 studies on the condition show a current worldwide prevalence rate of 8.2% (95% confidence interval [CI] = 5.7 to 11.7) with the highest prevalence in Africa at 17.2% (95% CI = 13 to 22.3). 4 In 1831, Baron Guillaume Dupuytren was the first person to formally present a lecture to the medical community on permanent contractions of the flexed fingers and publish his findings; 5 the disease now bears his name. 1 Since that time, many physicians and surgeons have attempted to treat Dupuytren's disease, but none have been fully successful at eradicating it.…”

“…15 In contrast, Dupuytren's disease is a fibroproliferative disease of the palmar fascia that can produce a slow-progressing flexion deformity that prevents the patient from extending the digit (Figure 2). 4…”

Extrahepatic Manifestations in Alcoholic Liver Disease

“…The prevalence of Dupuytren's contracture, a benign fibroproliferative condition with formation of collagen knots and fibres over the palmar fascia is higher in AUD patients particularly those with concomitant diabetes. 133 Patients with ALD most often suffer from sarcopenia (skeletal muscle loss) which can be attributed to hepatocellular dysfunction as well as direct toxic effect of alcohol and its metabolites on muscle tissue leading to reduced synthesis of protein and anabolic resistance and an impaired response to nutritional interventions. 134,135 The prevalence of sarcopenia is higher in alcoholic hepatitis than that in alcoholic cirrhosis which may be attributed to the presence of considerable amount of acute inflammatory response in alcoholic hepatitis.…”

Actual Aspects of Surgical Treatment of Dupuytren's Disease (Literature Review)

“…За характером супутньої патології як прогностично несприятливим щодо шансів прогресування хвороби й пролонгованого терміну анатомо-функціонального відновлення кисті після оперативної корекції, за даними Nader Salari, Mohammadbagher Heydari et al (2020), є цукровий діабет І типу, найбільша частка пацієнтів становить 34,1% (95% ДІ 25-44,6%) [27].…”