One of the most dangerous types of cyclic effects, especially inherent in several regions in the world, is the alternating impact of wetting and drying on concrete and reinforced concrete structures. In the current scientific literature and practice, there is not enough fundamental and applied information about the resistance to wetting and drying of variotropic concretes obtained by centrifugal compaction methods. The purpose of the study was to investigate the effect of various technological, compositional, and other factors on the final resistance of variotropic concrete to alternating cycles of moistening and drying. For this, special methods for testing concrete samples were used in the work. It has been established that after strength gain as a result of hydration, there is a tendency for strength loss due to concrete wear. An acidic medium has the most negative effect on the strength characteristics of concretes made using various technologies, compared with neutral and alkaline media. The loss of strength of concrete when moistened in an acidic medium was greater than in alkaline and especially neutral media. The vibrocentrifuged concrete turned out to be the most resistant to the impact of an aggressive environment and the cycles of moistening and drying, compared to the centrifuged and vibrated concrete. The drop in strength was up to 7% less compared to centrifuged concrete and up to 17% less than vibrated concrete.