Assessment of the technical condition of large-panel buildings, due to their on-going use and covering resulting from thermomodernization works, is problematic. Results from non-destructive tests (NDT) are subjected to high uncertainty. Destructive tests, which give results with the highest level of confidence, are practically not used. Local sampling for testing gives only a partial image of the condition of a prefabricated building. In this type of construction, joints connecting the precast elements are the most vulnerable to degradation. Access to them is technically difficult. Demolition of this type of building is extremely rare. However, it is a unique opportunity to perform a full spectrum of both NDT and destructive testing. This gives an opportunity for large-scale demolition sampling to identify hidden defects and compare the results obtained by different methods. The comparison of results allows for the scaling of NDT methods and reveals the presence of typical relationships. The paper presents visual, non-destructive, and destructive tests’ results of an over 40-year-old large-panel building scheduled for demolition. The design of this building is repetitive and similar to solutions found in thousands of other buildings. The usefulness of particular research methods for evaluating the technical condition of prefabricated buildings has been determined.