Currently, one of the topical areas of application of artificial intelligence methods in industrial production is neural networks, which allow for predicting the performance properties of products and structures that depend on the characteristics of the initial components and process parameters. The purpose of the study was to develop and train a neural network and an ensemble model to predict the mechanical properties of lightweight fiber-reinforced concrete using the accumulated empirical database and data from construction industry enterprises, and to improve production processes in the construction industry. The study applied deep learning and an ensemble of regression trees. The empirical base is the result of testing a series of experimental compositions of fiber-reinforced concrete. The predicted properties are cubic compressive strength, prismatic compressive strength, flexural tensile strength, and axial tensile strength. The quantitative picture of the accuracy of the applied methods for strength characteristics varies for the deep neural network method from 0.15 to 0.73 (MAE), from 0.17 to 0.89 (RMSE), and from 0.98% to 6.62% (MAPE), and for the ensemble of regression trees, from 0.11 to 0.62 (MAE), from 0.15 to 0.80 (RMSE), and from 1.30% to 3.4% (MAPE). Both methods have shown high efficiency in relation to such a hard-to-predict material as concrete, which is so heterogeneous in structure and depends on many factors. The value of the developed models lies in the possibility of obtaining additional useful information in the process of preparing highly functional lightweight fiber-reinforced concrete without additional experiments.