Dural sinus thrombosis in children with cancer

Reddingius, Roel E.; Patte, Catherine; Couanet, D.; Kalifa, Chantal; Lemerle, J

doi:10.1002/(sici)1096-911x(199710)29:4<296::aid-mpo11>3.0.co;2-9

Cited by 30 publications

(6 citation statements)

References 32 publications

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“…During pregnancy or puerperium, a significant increase in the risk of cerebral venous thrombosis was associated with caesarian delivery (OR 3.1), increasing maternal age (OR 2.5), presence of comorbidities including hyperhemesis (OR 14.2), intercurrent infections (OR 3.45) and maternal hypertension [18] Neurosurgery [19] Meningitides [20] Arterovenous malformation [21] Sepsis (sinusitis, mastoiditis, cellulitis) [22,23] Stroke and hemorrhage Space-occupying lesions Jugular catheterization Systemic Dehydration (diabetic ketoacidosis) Septicemia [24] Pregnancy and puerperium [5] Inflammatory bowel disease [25] Malignancy [26] Sarcoidosis [27] Collagen disease (Behcet's syndrome, SLE, Sjögren's syndrome) [28][29][30] Homocysteinuria [31] Nephrotic syndrome [32] Autoimmune thyroiditis Drugs…”

Section: Etiologymentioning

confidence: 99%

Epidemiology of Cerebral Vein and Sinus Thrombosis

Agnelli

Verso²

2007

Handbook on Cerebral Venous Thrombosis

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Cerebral venous thrombosis is a serious but potentially treatable cerebrovascular disorder that, unlike arterial cerebrovascular disorder, often affects young adults and children. Cerebral venous thrombosis is a challenging condition for the clinicians because of the wide spectrum of its clinical presentation. Although recognized for more than 100 years, its incidence has been underestimated in the past due to the lack of accurate diagnostic techniques.

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Section: Etiologymentioning

confidence: 99%

Epidemiology of Cerebral Vein and Sinus Thrombosis

Agnelli

Verso²

2007

Handbook on Cerebral Venous Thrombosis

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“…Kyrnetskiy et al identified 51 children with cancer and intracranial hemorrhages, which included subdural, epidural, subarachnoid and intracerebral (parenchymal or intraventricular) hemorrhages, in an 18-year retrospective review and found 30 children with brain tumors, 19 with leukemia and 2 with lymphoma 12 . There is literature focusing on stroke in children with selected neoplasms (either leukemia, specifically ALL, or brain tumors) 13–15 , or characterizing single stroke type (intracerebral hemorrhage, ischemic stroke or cerebral sinovenous thrombosis (CSVT) in children with cancer 12, 16, 17 .…”

Section: Introductionmentioning

confidence: 99%

Hemorrhagic and Ischemic Stroke in Children With Cancer

Noje

Cohen

Jordan

2013

Pediatric Neurology

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BACKGROUND Adult survivors of childhood cancer have an increased risk of cerebrovascular disease; little is known about early stroke risk in childhood cancer. Our objectives were to assess stroke prevalence in children with cancer; to establish cancer and stroke type; and to determine if modifiable risk factors for stroke were present. METHODS Children with stroke and cancer were compared to all children seen for cancer at a single institution from 2000–2009. An international classification of disease-9th version code search and search of existing pediatric oncology and stroke databases identified children <18 years with ischemic stroke, intracerebral hemorrhage and cerebral sinovenous thrombosis. RESULTS Of 1,411 children with cancer, 15 had stroke (1.1%, 95% CI: 0.6–1.7%). Strokes were 7 intracerebral hemorrhages, 5 ischemic strokes (1 of them followed by intracerebral hemorrhage), and 3 sinovenous thromboses. Stroke occurred at a median of 5 months post-cancer diagnosis. Ten children with strokes had hematologic malignancies and 5 had brain tumors. Thirteen patients died post-stroke, 8 via withdrawal of care. White blood cell count ≥48,000/mm3 was found in 4 children, all with intracerebral hemorrhage. Five of 7 children with intracerebral hemorrhage had platelets <50,000/mm3 CONCLUSIONS Stroke has a prevalence of approximately 1% in children with cancer. Hemorrhagic stroke and ischemic stroke occur with approximately equal frequency; children with leukemia and brain tumors are at greatest risk.

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“…Unfortunately, this was not considered in patient A while under our care. Previous reports have described a variety of thrombotic events in children with disseminated neuroblastoma [13,14]. These studies demonstrate that a minority of children with neuroblastoma develop a poorly characterized prothrombotic state with increased platelet-aggregating activity as a result of excess thrombin production from the tumor and are at risk from venous occlusion at a variety of sites [15].…”

Section: Discussionmentioning

confidence: 86%

Hepatic Cirrhosis and Portal Hypertension in Neuroblastoma

Yule

Anderson

2000

Pediatric Hematology and Oncology

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Hepatic portal hypertension is an unusual complication of cancer therapy. The authors report 2 children under the age of 18 months with disseminated neuroblastoma who developed cavernous transformation of the portal vein during chemotherapy. While the older child remains well, the second patient succumbed from overwhelming variceal hemorrhage as a result of this condition. Full recovery of hepatic function is not invariable following the regression of extensive liver infiltration by neuroblastoma and consideration should be given to follow-up Doppler ultrasound imaging of the hepatic portal system in affected infants.

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Dural sinus thrombosis in children with cancer

Cited by 30 publications

References 32 publications

Epidemiology of Cerebral Vein and Sinus Thrombosis

Epidemiology of Cerebral Vein and Sinus Thrombosis

Hemorrhagic and Ischemic Stroke in Children With Cancer

Hepatic Cirrhosis and Portal Hypertension in Neuroblastoma

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