Duration Mismatch Negativity and P3a in First-Episode Psychosis and Individuals at Ultra-High Risk of Psychosis

Abstract

These results suggest that MMN, as well as P3a, to duration deviants are reduced in very early stages of a psychotic illness including those in an at-risk mental state. Both should be considered as potential markers of the prodrome.

Delayed preattentional functioning in early psychosis patients with cannabis use

“…Consistent with previous findings, the non-using early psychosis group showed a marked reduction in both MMN (Javitt et al 2000;Brockhaus-Dumke et al 2005;Salisbury et al 2006;Todd et al 2008;Jahshan et al 2009;Hermens et al 2010;Bodatsch et al 2011;Atkinson et al 2012) and P3a (Hirayasu et al 1998;Salisbury et al 1998;Hermens et al 2010;) amplitudes compared to controls. Notably, EP patients who used cannabis showed a different pattern of neurophysiological expression for both MMN and P3a components compared to non-using patients, with the seemingly additive impairment of significantly delayed MMN latencies.…”

“…Compared to the chronic schizophrenia literature, few studies have examined MMN in first episode or recent onset psychosis. Consistent with established schizophrenia patients, significantly reduced MMN amplitude has been reported in prodromal (Brockhaus-Dumke et al 2005;Bodatsch et al 2011), ultra-high risk (UHR;Atkinson et al 2012), first episode (Salisbury et al 2007;Jahshan et al 2009;Hermens et al 2010) and recent-onset (e.g. Javitt et al 2000;Todd et al 2008;Jahshan et al 2012) psychosis samples.…”

Mismatch negativity is a breakthrough biomarker for understanding and treating psychotic disorders

“…Perez et al (21) extended these findings to show that MMN amplitude also "forecasts" the time lag to psychosis onset in CHR individuals; those with more severe MMN abnormalities had shorter times to psychosis. These CHR and related studies (21,(23)(24)(25)(26) draw attention to the importance of identifying early biologic markers of disease vulnerability for predicting the development of psychosis and enhancing individualized risk-estimation/ prevention strategies (20).…”

Mismatch Negativity reduction in the left cortical regions in first-episode psychosis and in individuals at ultra high-risk for psychosis

“…In the last decade, several studies have reported a decrement of MMN amplitude in individuals identified as being at ultra high-risk for psychosis (UHR) (Brockhaus-Dumke et al, 2005;Bodatsch et al, 2010;Atkinson et al, 2012;Jahshan et al, 2012;Shaikh et al, 2012). UHR corresponds to a prepsychotic or 'prodromal' phase in which subthreshold psychotic symptoms and cognitive decline are observed (Yung and McGorry, 1996).…”