Duration of the depressive episode is correlated with ganglion cell inner plexifrom layer and nasal retinal fiber layer thicknesses: Optical coherence tomography findings in major depression

Yıldız, Mesut; Alim, Sait; Batmaz, Sedat; Demir, Selim; Songur, Emrah; Ortak, Hüseyin; Demirci, Kadir

doi:10.1016/j.pscychresns.2016.04.011

Cited by 65 publications

(39 citation statements)

References 42 publications

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“…is another limitation that make it difficult to generalize the results and to make comparisons between different subgroups. It was speculated that longer periods of the recent depressive episode cause more retinal atrophy by Yıldız et al [45]. Recent depressive episode of patients is another issue that should be considered while evaluating retinal degeneration due to schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of retinal nerve fiber layer, macular, and choroidal thickness in schizophrenia: spectral optic coherence tomography findings

Topçu-Yılmaz

Aydın

İlhan

2018

Psychiatry and Clinical Psychopharmacology

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OBJECTIVES:The study was performed to evaluate the retinal nerve fiber layer (RNFL), macular, and subfoveal choroidal thickness (SFCT) in patients with schizophrenia and healthy controls using spectral domain optical coherence tomography (SD-OCT). METHODS: Fifty-nine schizophrenic patients and 36 age-and sex-matched healthy volunteers were enrolled in this cross-sectional clinical study. The RNFL, macular, and SFCT thickness measurements obtained by SD-OCT were compared between the groups.

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Section: Discussionmentioning

confidence: 99%

Evaluation of retinal nerve fiber layer, macular, and choroidal thickness in schizophrenia: spectral optic coherence tomography findings

Topçu-Yılmaz

Aydın

İlhan

2018

Psychiatry and Clinical Psychopharmacology

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“…Initial applications of OCT were limited mainly to ophthalmic diseases, but several studies found that the changes of the neural layers of the retina might predict CNS pathology such as cortical atrophy with patients in many non-ocular diseases [11,12]. Similarly, several studies on OCT tested the progression of the psychiatric disorders and found the thinning of RNFL or macula in patients with schizophrenia (SZ) [13], bipolar disorder (BP) [14], major depression (MD) [15], and anorexia nervosa [16]. However, the retinal findings were not strongly correlated with clinical symptoms in major psychiatric diseases [10].…”

Section: Introductionmentioning

confidence: 99%

Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer

et al. 2020

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Sleep may play a fundamental role in retinal regulation and the degree of retinal variables. However, no clinical study has investigated optical coherence tomography (OCT) parameters in patients with primary insomnia. All participants were evaluated with the insomnia severity index (ISI) and the Pittsburgh sleep quality index (PSQI). The retinal nerve fiber layer (RNFL), ganglion cell layer (GC), inner plexiform layer (IPL), macula and choroidal (CH) thickness were compared between 52 drug-naïve patients with primary insomnia and 45 age-gender-BMI-smoke status matched healthy controls (HC). The patients with primary insomnia differed from the HC regarding RNFL-Global (p = 0.024) and RNFL-Nasal inferior (p = 0.010); IPL-Temporal (p < 0.001), IPL-Nasal (p < 0.001); CH-Global (p < 0.001), CH-Temporal (p = 0.004), CH-Nasal (p < 0.001), and CH-Fovea (p = 0.019). ISI correlated with RNFL-Global and RNFL-Nasal inferior. The regression analysis revealed that ISI was the significant predictor for the thickness of RNFL- Nasal inferior (p = 0.020), RNFL-Global (p = 0.031), and CH-Nasal (p = 0.035) in patients with primary insomnia. Sleep disorders are seen commonly in patients with psychiatric, including ocular diseases. Adjusting the effect of insomnia can help to clarify the consistency in findings of OCT.

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“…Another psychiatric disorder in which retinal findings are investigated using OCT is major depressive disorder. No significant difference was found in the two studies in patients with Major depressive disorder [17,18]. In another study with 13 women with Anorexia nervosa, the macular thickness was found to be decreased in anorexia cases, while no difference was found in RNFL thickness between groups [19].…”

Section: Discussionmentioning

confidence: 84%

“…As a result of a meta-analysis of case-control studies related to this issue and performed in 2018, it was stated that RNFL can be used as a diagnostic tool in schizophrenia [16]. In addition to studies about schizophrenia, there are researches that ocular findings have been evaluated by using OCT in patients with Major depressive disorder, ADHD and Anorexia nervosa [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Retinal nerve fiber layer, macular thickness and anterior segment measurements in attention deficit and hyperactivity disorder

Ayyıldız

2019

Psychiatry and Clinical Psychopharmacology

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AIM: We aimed to explore whether there is difference in terms of Retinal Nerve Fiber Layer (RNFL) thickness, macula thickness and anterior segment structures of the eye between children and adolescents with ADHD and healthy controls. METHOD: Children and adolescents aged 8-16 years who were admitted to the Child Psychiatry outpatient clinic of Ahi Evran University Hospital diagnosed with ADHD constituted the study group. Exclusion criteria included patients who had any systemic/ocular or psychiatric disorder other than ADHD and patients who had any psychopharmacological treatment. Participants in the control group were children and adolescents who applied to the outpatient clinic of Ophthalmology at the same hospital with no chronic medical or psychiatric disorder. Groups were compared in terms of central macular thickness, retinal nerve fibre layer thickness (RNFL), central corneal thickness, corneal diameter, mean corneal radius of curvature, anterior chamber depth, and axial length using Optical Coherence Tomography (OCT) and Optical Biometry. RESULTS: Data obtained from the measurements of 60 eyes of 30 patients with ADHD and 60 eyes of 30 patients of the control group were evaluated. Groups were similar in terms of age and gender. Corneal thickness (p = 0.001) and axial length (p = 0.04) values were significantly higher in ADHD group while the mean corneal curvature radius (p = 0.03) was significantly lower in ADHD group than in controls. No significant difference was observed between groups in terms of RNFL thickness, macular thickness, the corneal diameter, and anterior chamber depth measurements. CONCLUSION: In recent years, the use of OCT in neuropsychiatric diseases has increased the interest in identifying possible biomarkers and the elucidation of neurodegenerative and neurodevelopmental mechanisms that contribute to the nature of these diseases. Differences in the ophthalmic anatomical structures observed between healthy controls and cases with ADHD, which is a neurodevelopmental disorder, need to be supported by longitudinal studies with a larger sample and using OCT in connection with brain imaging.

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Duration of the depressive episode is correlated with ganglion cell inner plexifrom layer and nasal retinal fiber layer thicknesses: Optical coherence tomography findings in major depression

Cited by 65 publications

References 42 publications

Evaluation of retinal nerve fiber layer, macular, and choroidal thickness in schizophrenia: spectral optic coherence tomography findings

Evaluation of retinal nerve fiber layer, macular, and choroidal thickness in schizophrenia: spectral optic coherence tomography findings

Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer

Retinal nerve fiber layer, macular thickness and anterior segment measurements in attention deficit and hyperactivity disorder

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