Duration of the increase in amniotic fluid index (AFI) after acute maternal hydration

Joshi

Int J Reprod Contracept Obstet Gynecol

2013

Background: Pregnancy represents a special physiological state during which the use of drug is of growing concern due to risk of teratogenicity. High risk pregnancy is common threat to mother and foetus. Therefore, our aim was to study the drug utilization and morbidity pattern in high risk pregnancy in hospitalized pregnant women. Methods: An observational, prospective study was carried out in 250 patients for 6 months in the tertiary care hospital. Protocol was approved by the Institutional Review Board (IRB). The data were collected in a pre-designed proforma. Data were analysed by using SPSS version 20.0 Software. Results: Among 250 patients, 19 (7.6%), 218 (87.2%) and 13 (5.2%) were of less than 20, 20 to 30 and more than 30 years of age respectively. About 68.8% women had complained of abdominal pain and 67.6% had weakness followed by headache / body ache (47.2%), oedema (26.4%) and vomiting (18.8%). Iron (91.2%) and calcium (84.5%) were the commonest drugs prescribed followed by folic acid (59.6%), protein powder (54.8%), vitamin C (46.8%) and isoxsuprine (26.6%). As per FDA Drug Risk Category, Category-A (82.21%) was most frequently prescribed followed by Category-B (15.64%) and Category-C (2.15%). Percentage of drugs prescribed by generic name and from essential drug list was 62.80% and 80.79%. Conclusion: Iron, Calcium and Folic acid were most commonly prescribed drugs. There is lesser number of drugs prescribed by generic name suggesting need for sincere efforts to improve situation. [Int J Reprod Contracept Obstet Gynecol 2013; 2(3.000): 372-378

Section: Discussionmentioning

confidence: 99%

A study of morbidity and drug utilization pattern in indoor patients of high risk pregnancy at tertiary care hospital

Joshi

Int J Reprod Contracept Obstet Gynecol

2013

“…Inputs into amniotic fluid include the dilute fetal urine and the isotonic lung liquid, and pathways of exit of fluid include fetal swallowing, and transmembrane fluxes [12,13]. Thus abnormalities of amniotic fluid volume (oligo- and polyhydramnios) can result from abnormalities in fetal renal function, and oligohydramnios can be corrected, to some extent, by increase in maternal hydration [14,15]. Under normal circumstances the fetal fluid osmolality follows that of the mother, and fluid exchange occurs across the placenta, as well as across the amnion/chorion [16].…”

Section: Placenta and Fetal Fluid Compartmentsmentioning

confidence: 99%

Aquaporins in development – a review

Liu

Wintour

2005

Reprod Biol Endocrinol

Water homeostasis during fetal development is of crucial physiologic importance. It depends upon maternal fetal fluid exchange at the placenta and fetal membranes, and some exchange between fetus and amniotic fluid can occur across the skin before full keratinization. Lungs only grow and develop normally with fluid secretion, and there is evidence that cerebral spinal fluid formation is important in normal brain development. The aquaporins are a growing family of molecular water channels, the ontogeny of which is starting to be explored. One question that is of particular importance is how well does the rodent (mouse, rat) fetus serve as a model for long-gestation mammals such as sheep and human? This is particularly important for organs such as the lung and the kidney, whose development before birth is very much less in rodents than in the long-gestation species.

“…It is now plausible to hypothesize that continuous maternal hydration is an effective method to prevent amniotic fluid volume reduction and oligohydramnios in pregnancies with fetal gastroschisis. Malhotra and Deka [15] described a significant increase in AFI 3 h after maternal hydration but not after 24 and 48 h. However, the mean gestation in that study was 35 weeks.…”

Section: Discussionmentioning

confidence: 49%

“…Significant improvement in amniotic fluid volume after maternal oral hydration has also been shown in pregnancies with oligohydramnios [13][14][15] .…”

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Changes in Amniotic Fluid Index after Maternal Oral Hydration in Pregnancies with Fetal Gastroschisis: Initial Observations

Brizot¹,

Liao²,

Nomura³

et al. 2010

Fetal Diagn Ther

Objective: To evaluate the effect of maternal oral hydration on amniotic fluid index (AFI) in pregnancies with fetal gastroschisis. Methods: AFI was evaluated at 24-hour intervals, during 4 consecutive days, under a continuous maternal oral water hydration regimen, in singleton pregnancies with isolated fetal gastroschisis. Results: Nine pregnancies were examined at a mean gestational age of 31.6 weeks (±1.4) and mean maternal daily oral water intake was 3,437 (±810) ml. Mean AFI on days 0–3 were 13.2 (±2.9), 14.8 (±3.3), 14.5 (±3.1) and 14.8 (±2.6), respectively. AFI on day 0 was significantly lower compared to all the other 3 days (p = 0.01 and 0.02). Significant correlation was found in relative difference in AFI between day 0 and day 1 and gestational age (r = –0.67, p = 0.05) and the amount of water intake in the previous 24 h (r = 0.76, p = 0.02). Conclusion: Maternal oral water hydration significantly increases AFI in pregnancies with isolated fetal gastroschisis.