During liver regeneration following right portal embolization the growth rate of liver metastases is more rapid than that of the liver parenchyma

Élias, Dominique; Baère, Thierry De; Roche, Alain; Ducreux, Michel; Leclère, J.; Lasser, P

doi:10.1046/j.1365-2168.1999.01154.x

Cited by 332 publications

(208 citation statements)

References 14 publications

Supporting

Mentioning

177

Contrasting

Unclassified

Order By: Relevance

“…PVE increases the anticipated future liver volume and allows surgery in patients who would otherwise be contraindicated for resection. The potential disadvantage of PVE is that earlier studies have suggested that it may stimulate tumour growth and lead to reduced long-term survival (Elias et al, 1999;Kokudo et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…This may reflect either a rapid disease progression in patients who are selected for PVE or that PVE stimulates tumour growth. Tumour growth exceeding that of the normal liver parenchyma has been shown on imaging following PVE in patients with contra lateral lobe metastases (Elias et al, 1999), and the tumour-doubling time following PVE has been shown to be reduced from 92 to 76 days (Kokudo et al, 2001). There have been concerns that PVE may increase the risk of disease recurrence after curative resection (Kokudo et al, 2001;Pamecha et al, 2009).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effect of portal vein embolisation on the growth rate of colorectal liver metastases

et al. 2009

View full text Add to dashboard Cite

Portal vein embolisation (PVE) is used to increase the remnant liver volume before major liver resection for colorectal metastases. The resection rate after PVE is 60 -70%, mainly limited by disease progression. The effect of PVE on tumour growth rate has not been investigated. The objective of this study was to compare the growth characteristics of resected colorectal liver metastases in patients undergoing pre-operative PVE with those of matched controls who had not undergone PVE. There were 22 patients who had undergone preoperative PVE and 20 matched controls. Tumour growth rate was calculated by the change in tumour volume (CT/MRI volumetric assessment) from diagnosis to resection. Resected histological specimens were examined by two histopathologists independently for cell differentiation, percentage tumour cell necrosis and mitotic rate. Immunochemical staining with Ki67 was carried out using the MIB-1 monoclonal antibody and quantified using a Glasgow cell-counting graticule. The groups were comparable in demographics, stage of primary disease, volume of liver metastases at presentation and chemotherapy received. The tumour growth rate calculated from imaging was more rapid in the PVE group compared with that in controls (control: 0.05 ± 0.25 ml day À1 , PVE: 0.36 ± 0.68 ml day À1 , P ¼ 0.06). Histology showed no difference in the degree of differentiation, extent of necrosis or apoptosis between the two groups. However, mitotic rate was higher post PVE, as was the proliferation index Ki67 (P ¼ 0.04). This study has confirmed that tumour growth rate increased following PVE and that this is related to increased tumour cell division.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effect of portal vein embolisation on the growth rate of colorectal liver metastases

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Analogical progression of primary and secondary tu- mors after foregoing resection was also noted in experimental [58][59][60] and clinical [61,62] studies. Partial heaptectomy impacted on the growth of tumor size in the remaining places of diseased liver.…”

Section: The Hypothesis Of Genome Intrusionmentioning

confidence: 62%

Functions of hereditary immunity and xenogamy in cancer origin and pandemic spread

Rumyantsev¹

2011

OJI

View full text Add to dashboard Cite

The efficacy of means exploited currently for cancer prevention and treatment appeared to be very low. New insights into the origin of the disease are sorely needed. The present article synthesizes the results from integrative reconsideration of actual data on cancer from the viewpoint of recent developments in pathology, epidemiology, immunology, genetics, and evolution. In contrast to the 80 years old hypothesis of somatic mutative origin of carcinogenesis, the revealed set of evidence showed the origin of cancerous clones is based on inherent constitutional incongruence between the regulators of cell physiology and their targets realized in inherent immunity of cancerous cells to normal regulation of cell replication and tissue growth. The incongruence arises out of both genome mutations which led to interethnic differences in the regulator-receptor structures and intercourse between ethnoses, the regulator-receptor evolution of which has been processed to deal with different ecologic conditions. The current pandemic spread of cancer is brought about growing expansion of interethnic xenogamy favored by growing industrialization, urbanization, globalization, and migration. The proposed hypothesis of genome intrusion in the origin of cancer induces new research ideas and proposals for cancer prevention and therapy.

show abstract

“…Since the first description of the potential of intrahepatic tumor enlargement after PVE (24), accumulating evidence has shown that PVE stimulates tumor growth in both embolized and non-embolized liver segments (13,25). Hayashi et al (26) reported that the median tumor growth rate of primary liver cancer in the embolized lobe after PVE was approximately two times greater than that before PVE.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effectiveness of Preoperative Portal Vein Embolization in Patients with Chronic Liver Disease: Gelfoam versus Gelfoam-Coil Combination

Shin

Chang

Choo

et al. 2015

J Korean Soc Radiol

View full text Add to dashboard Cite

show abstract

During liver regeneration following right portal embolization the growth rate of liver metastases is more rapid than that of the liver parenchyma

Abstract: In functionally intact liver parenchyma, during hepatic regeneration or hypertrophy, the growth rate of metastases is more rapid that that of the liver parenchyma. However, a wide variation in growth rate is observed between patients and between metastases.

Cited by 332 publications

References 14 publications

Effect of portal vein embolisation on the growth rate of colorectal liver metastases

Effect of portal vein embolisation on the growth rate of colorectal liver metastases

Functions of hereditary immunity and xenogamy in cancer origin and pandemic spread

Comparison of the Effectiveness of Preoperative Portal Vein Embolization in Patients with Chronic Liver Disease: Gelfoam versus Gelfoam-Coil Combination

Contact Info

Product

Resources

About