When considering particles produced in reactive plasmas, their basic properties, such as refractive index and grain size often need to be known. They can be constrained both ex-situ, e.g., by microscopy, and in-situ by polarimetry, i.e., analyzing the polarization state of scattered light. Polarimetry has the advantage of temporal resolution and real-time measurement, but the analysis is often limited by the assumption of single scattering and thus optically thin dust clouds. This limits the investigation of the growth process typically to grain sizes smaller than about 200 nm. Using 3D polarized radiative transfer simulations, however, it is possible to consider multiple scattering and to analyze the properties of dense particle clouds. We study the impact of various properties of dust clouds on the scattering polarization, namely the optical depth of the cloud, the spatial density distribution of the particles, their refractive index as well as the particle size dispersion. We find that ambiguities can occur regarding optical depth and spatial density distribution as well as regarding refractive index and particle size dispersion. Determining the refractive index correctly is especially important as it has a strong impact on the derived particle sizes. With this knowledge, we are able to design an in-situ diagnostics strategy for the investigation of the particle growth process based on radiative transfer simulations which are used to model the polarization over the whole growth process. The application of this strategy allows us for the first time to analyze the polarization measured during a growth experiment in a reactive argon-acetylene plasma for particle radii up to 280 nm.