Depressive symptoms and conflict negatively affect romantic relationships, but does this differ among couples? Using a stress generation theory framework, we aim to understand the types of profiles based on both partners’ responses of depressive symptoms and conflict. We used data from 1,598 German couples (different-sex) and conducted latent profile analyses in order to examine if there are different profiles of couples related to the male and female partners’ depressive symptoms and levels of conflict. We then examined if these profiles predicted relationship instability 1 year later. Our results revealed four profiles: congruent low conflict, incongruent female moderate conflict, incongruent male moderate conflict, and congruent moderate conflict. Both males and females in the congruent low and moderate conflict profiles showed agreement in their level of depressive symptoms and conflict, hence congruent. However, males and females differed in their levels of depressive symptoms and conflict in two incongruent profiles. For example, females in the incongruent female moderate conflict profile had higher levels of depressive symptoms and conflict than their partners. Prior depressive symptoms and conflict increased the odds of being in the incongruent female moderate conflict, incongruent male moderate conflict, and congruent moderate conflict profiles compared to the congruent low conflict profile. The congruent moderate conflict profile had the highest probability of relationship instability 1 year later. This study adds to our knowledge about the different profiles of couples with depressive symptoms and conflict as well as relationship instability.