Incidence of social isolation i.e., the state of being disconnected from social relationships, has increased significantly in the aftermath of Covid-19. In turn, the emerging phenomenon of social isolation across the world has impacted the interpersonal relations among married couples, among other consequences. This research studies dyadic coping and psychological wellbeing among married individuals in India and also explores whether dyadic coping strategies can predict psychological wellbeing of people afflicted by social isolation in the post-Covid-19 scenario. Results of the study indicate that dyadic coping predicts psychological wellbeing to a great extent. Among males, supportive dyadic coping impacts the psychological wellbeing while among females, common dyadic coping prominently predicts psychological wellbeing. All dimensions of dyadic coping have a significant correlation with psychological wellbeing except Negative Dyadic Coping by Oneself and Negative Dyadic Coping of the Partner, which do not seem to have any association with the latter.