Dyke Davidoff Masson syndrome a rare cause of schizoaffective disorder: A case report and review of the literature

Hamza, Nouha; Hdiji, Olfa; Kacem, Hatem Hadj; Farhat, Nouha; Sakka, Salma; Dammak, Mariem; Mhiri, Chokri

doi:10.1016/j.encep.2019.01.003

Cited by 4 publications

(6 citation statements)

References 7 publications

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“…Intellectual disability, depressive symptoms, suicidal ideation and behavioral symptoms were documented in a 21-year-old woman with a history of systemic lupus erythematosus [ 7 ]. Although the underlying pathophysiological mechanism had not yet been well clarified, our results added some positive evidence for the association between psychiatric disorder and DDMS [ 7 – 12 ]. The organic disorders associated with central nervous system might lead to psychosis [ 17 – 19 ].…”

Section: Discussionmentioning

confidence: 63%

“…The characterization of neuropsychiatric manifestations of DDMS was one of the main contributions of this study. Very few DDMS cases complicated by psychiatric manifestations in DDMS were reported [ 7 – 12 ]. The involvement psychiatric disorders including schizophrenia, schizoaffective disorder, bipolar I mania, depressive episode and emotional dysregulation have been reported in patients with DDMS [ 7 – 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Very few DDMS cases complicated by psychiatric manifestations in DDMS were reported [ 7 – 12 ]. The involvement psychiatric disorders including schizophrenia, schizoaffective disorder, bipolar I mania, depressive episode and emotional dysregulation have been reported in patients with DDMS [ 7 – 12 ]. Intellectual disability, depressive symptoms, suicidal ideation and behavioral symptoms were documented in a 21-year-old woman with a history of systemic lupus erythematosus [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Few DDMS patients with contralaterally crossed cerebellar atrophy have been reported [ 6 ]. However, cases on the correlation between DDMS and neuropsychiatric symptoms is rarely reported [ 7 – 12 ]. To the best of our knowledge, none of the cases till date were presented with ear malformations.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and neuroimaging findings of seven patients with Dyke Davidoff Masson syndrome

et al. 2021

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Background DDMS is a rare disease diagnosed by clinical and radiological characteristics. But the complexity of radiological and clinical manifestations of DDMS has become a challenge diagnostically. To date, the reported cases with DDMS had highly varied clinical manifestations including seizures, contralateral hemiplegia/hemiparesis, facial asymmetry, mental retardation, etc. In addition to typical clinical findings, some new characteristics have been recently added to the spectrum of DDMS. However, few cases have been reported to be associated with neuropsychiatric symptoms according to the literature. This study aimed to investigate the neuropsychiatric manifestations associated with Dyke-Davidoff-Masson syndrome (DDMS) and related imaging findings. Methods This study included 7 patients diagnosed with DDMS between 2014 and 2020. The clinical characteristics, neuropsychiatric manifestations, and radiological results were retrospectively evaluated. Results Seven patients (five males and two females) with a mean age of 28.0 ± 9.73 (range 15.0–41.0) years were included. Five patients were admitted to the psychiatric unit due to psychological and behavioral disorders. Two patients were referred to the neurology unit mainly due to epilepsy. Six patients had epileptic seizures, 4 had hemiplegia, 3 had mental retardation, 2 patients had external ear deformities, and 2 had facial asymmetry. Neuropsychiatric symptoms were presented in 6 (85.7 %) cases. Cases 2–6 developed affective disorders. Deficits in verbal communication, impairment of social interaction, lack of insight, adulia and hypobulia appeared in cases 1–4. Schizophrenia with apathy, and epileptic schizoid psychosis were observed in cases 4 and 5 respectively. Case 6 had behavioral disorders, hyperactivity, tic disorder, mental retardation, anxiety, catatonic symptoms and suicidal tendency. Case 7 had seizures and mental retardation, and no psychiatric symptoms were presented. Radiological examinations showed unilateral cerebral atrophy, enlarged lateral ventricles, and various compensatory hypertrophy of the skull in all cases. The midline structure has shifted to the affected side in 5(71.4 %) cases. Atrophy of the basal ganglia or brain stem was observed in 4(57.1 %) cases. Conclusions The hallmark imaging manifestations of DDMS facilitated the diagnosis in most cases. This study illustrated that a variety of psychoneurotic disorders and ear abnormalities were correlated with DDMS.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and neuroimaging findings of seven patients with Dyke Davidoff Masson syndrome

et al. 2021

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“…Etiologia DDMS wciąż nie została w pełni poznana, uważa się jednak, że choroba jest wynikiem uszkodzenia mózgu w trakcie życia płodowego lub we wczesnym dzieciństwie. W zależności od czasu działania czynnika uszkadzającego wyróżnia się dwa rodzaje DDMS: wrodzony lub nabyty (Hamza et al, 2019;Wang et al, 2021). Do klasycznej triady objawów należą napady padaczkowe, różnego stopnia upośledzenie umysłowe i porażenie/niedowład połowiczy (Abdul Rashid i Md Noh, 2018).…”

Section: Wprowadzenieunclassified

Dyke–Davidoff–Masson syndrome – a review of the literature

Potyrała,

Krawczuk,

Bieniasz

et al. 2023

Aktualn Neurol

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Dyke–Davidoff–Mason syndrome is an extremely rare medical condition that results from brain damage occurring during foetal life or early childhood. The aetiology of the syndrome can be congenital or acquired. The clinical presentation of the syndrome is variable, and depends on the extent of damage to the central nervous system. It most commonly manifests as epileptic seizures, intellectual disability, and hemiparesis/hemiplegia, which is usually preceded by the first seizure. It is suspected that intellectual impairment is a consequence of epilepsy. The spectrum of symptoms also includes psychiatric conditions, particularly psychotic disorders and mood disorders. Radiological manifestations of the syndrome include midline cerebral shift, widening of the Sylvian fissure, hemispheric aplasia/hypoplasia of the brain, ipsilateral cranial bone thickening, lateral ventricle enlargement, as well as hyperpneumatisation of the frontal and sphenoid bones, and the mastoid process. Diagnosis is mainly based on imaging tests such as computed tomography and magnetic resonance imaging, as well as neurological examination and electroencephalography. During the patient’s history-taking, particular attention should be paid to pregnancy history and the childhood period in order to identify potential etiological factors. No characteristic changes in laboratory tests indicating Dyke–Davidoff–Mason syndrome have been found. Treatment is primarily symptomatic. The greatest challenge for physicians is the control of epileptic seizures. Conservative treatment is initially employed. If proven to be ineffective, surgical treatment should be considered.

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Dyke-Davidoff-Masson Syndrome: Main clinical and radiological findings- systematic literature review

Rondão,

Hsu,

Centeno

et al. 2023

Seizure: European Journal of Epilepsy

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Dyke Davidoff Masson syndrome a rare cause of schizoaffective disorder: A case report and review of the literature

Cited by 4 publications

References 7 publications

Clinical characteristics and neuroimaging findings of seven patients with Dyke Davidoff Masson syndrome

Clinical characteristics and neuroimaging findings of seven patients with Dyke Davidoff Masson syndrome

Dyke–Davidoff–Masson syndrome – a review of the literature

Dyke-Davidoff-Masson Syndrome: Main clinical and radiological findings- systematic literature review

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