Dynamic agent of an injectable and self-healing drug-loaded hydrogel for embolization therapy

Zhou, Xiaowen; Li, Yongsan; Chen, Shuang; Fu, Ya nan; Wang, Shihui; Li, Guofeng; Tao, Lei; Wei, Yen; Wang, Xing; Liang, Junfeng

doi:10.1016/j.colsurfb.2018.09.016

Cited by 37 publications

(32 citation statements)

References 33 publications

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“…Embolization agents are essential for the treatment of various unresectable malignant tumors. A three-component dynamic self-healing hydrogel based on glycol-chitosan, carbazochrome, and DF-PEG was recently prepared to overcome the limitation of low therapeutic efficiency [30]. The controlled release of carbazochrome and the tunable decomposition of hydrogels were found to be achieved using DF-PEG with various concentrations.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…Hydrogels with Schiff base linkages are currently used in several biomedical fields (Figure 1), including drug delivery [29,30], tissue regeneration [31,32], wound healing [33,34], tissue adhesives [35], bioprinting [36], and biosensors [37]. This review highlighted the use of different Schiff base linkages as crosslinking strategies to prepare biologically relevant hydrogels that can be used in physiological environments.…”

Section: Introductionmentioning

confidence: 99%

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Hydrogels Based on Schiff Base Linkages for Biomedical Applications

2019

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Schiff base, an important family of reaction in click chemistry, has received significant attention in the formation of self-healing hydrogels in recent years. Schiff base reversibly reacts even in mild conditions, which allows hydrogels with self-healing ability to recover their structures and functions after damages. Moreover, pH-sensitivity of the Schiff base offers the hydrogels response to biologically relevant stimuli. Different types of Schiff base can provide the hydrogels with tunable mechanical properties and chemical stabilities. In this review, we summarized the design and preparation of hydrogels based on various types of Schiff base linkages, as well as the biomedical applications of hydrogels in drug delivery, tissue regeneration, wound healing, tissue adhesives, bioprinting, and biosensors.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydrogels Based on Schiff Base Linkages for Biomedical Applications

2019

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“…Aldehyde-modified PEG derivatives are an ideal choice as the crosslinking agents for self-healing chitosan hydrogel. [60,61] The molecular weights of these PEG derivatives are often concentrated in 2000 Da, [32,62] probably in order to smoothen their reacting with polysaccharides. As reported by Schultz KM et al, [63] when the size of the bis-thiol PEG polymers exceeded the average linear space of the maleimide functional sites on the high molecular weight heparin (HMWH), the crosslinking between the PEG and the HMWH was retarded and the gelation time of the PEG-Heparin hydrogel was prolonged, indicating that the steric constraints of the big crosslinkers would slow down the coupling reaction kinetics.…”

Section: Chitosan and Chitinmentioning

confidence: 99%

Advances in Injectable and Self‐healing Polysaccharide Hydrogel Based on the Schiff Base Reaction

Chen

2021

Macromol. Rapid Commun.

139

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Injectable hydrogel possesses great application potential in disease treatment and tissue engineering, but damage to gel often occurs due to the squeezing pressure from injection devices and the mechanical forces from limb movement, and leads to the rapid degradation of gel matrix and the leakage of the load material. The self-healing injectable hydrogels can overcome these drawbacks via automatically repairing gel structural defects and restoring gel function. The polysaccharide hydrogels constructed through the Schiff base reaction own advantages including simple fabrication, injectability, and self-healing under physiological conditions, and therefore have drawn extensive attention and investigation recently. In this short review, the preparation and self-healing properties of the polysaccharide hydrogels that is established on the Schiff base reaction are focused on and their biological applications in drug delivery and cell therapy are discussed.

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“…Thermal gelation of CS in the presence of G carried out to injectable hydrogels for the treatment of breast cancer [203], while mixed polysaccharide hydrogels, including CS-ALG [204] and CS-HA-NIPAAm [205,206] complexes, were designed to produce targeted delivery of anti-VEGF antibody [204], as well as pH-responsive systems for the DOX [205] and DOX@GO [206] vectorization to colon and breast cancer, respectively. Injectable hydrogels were also prepared using CS hydrophilic derivatives [207]; for example, CS modified with glycol moieties was covalently linked with PEG to obtain hydrogel materials for the release of self-healing [208] and photosensitizing [209] agents. In another approach, DOX@PLGA nanoparticles were inserted into the hydrogel structure, together with magnetic nanoparticles, to raise a more sustained release profile combined with magnetic ablation of breast cancer [210].…”

Section: Natural Polymersmentioning

confidence: 99%

Injectable Hydrogels for Cancer Therapy over the Last Decade

et al. 2019

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The interest in injectable hydrogels for cancer treatment has been significantly growing over the last decade, due to the availability of a wide range of starting polymer structures with tailored features and high chemical versatility. Many research groups are working on the development of highly engineered injectable delivery vehicle systems suitable for combined chemo-and radio-therapy, as well as thermal and photo-thermal ablation, with the aim of finding out effective solutions to overcome the current obstacles of conventional therapeutic protocols. Within this work, we have reviewed and discussed the most recent injectable hydrogel systems, focusing on the structure and properties of the starting polymers, which are mainly classified into natural or synthetic sources. Moreover, mapping the research landscape of the fabrication strategies, the main outcome of each system is discussed in light of possible clinical applications.

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Dynamic agent of an injectable and self-healing drug-loaded hydrogel for embolization therapy

Cited by 37 publications

References 33 publications

Hydrogels Based on Schiff Base Linkages for Biomedical Applications

Hydrogels Based on Schiff Base Linkages for Biomedical Applications

Advances in Injectable and Self‐healing Polysaccharide Hydrogel Based on the Schiff Base Reaction

Injectable Hydrogels for Cancer Therapy over the Last Decade

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