This paper aims at analyzing the sensitivity of the structural response of flexible rotors subjected to uncertain interval parameters. The interval approach encompasses both an uncertainty and sensitivity analyses. The uncertainty analysis consists in computing the interval uncertain structural responses by using the global optimization method. The sensitivity analysis computes the normalized relative sensitivity indices that quantify the degree of importance of each uncertain interval parameter on the uncertain structural responses of the flexible rotor. The uncertain structural responses and the sensitivity of the flexible rotor subjected to interval parameters are analyzed in terms of the Frequency Response Function (FRF), orbits, Campbell diagram, and run-up operating condition. Numerical simulation results illustrate the interval approach conveyed.