Dynamic and simultaneous MR measurement of R1 and R2* changes during respiratory challenges for the assessment of blood and tissue oxygenation

Remmele, Stefanie; Sprinkart, Alois M.; Müller, Andreas; Träber, Frank; Lehe, Marec von; Gieseke, Jürgen; Flacke, Sebastian; Willinek, Winfried A.; Schild, Hans H.; Sénégas, Julien; Keupp, Jochen; Mürtz, Petra

doi:10.1002/mrm.24864

Cited by 19 publications

(41 citation statements)

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“…In terms of potential clinical applications the signal to noise of individual images would be expected to be lower at 1.5 or 3 T in a large bore magnet, but this may be compensated by larger voxels. Relaxivity of oxygen in blood and tissue is reported to show complex effects on R 1 and

R_{2}^{*}

, but effective studies of R 1 and

R_{2}^{*}

response to oxygen breathing have been reported recently in human tumors .…”

Section: Discussionmentioning

confidence: 99%

Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response

et al. 2013

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Purpose To examine the potential use of BOLD (Blood Oxygenation Level Dependent) and TOLD (Tissue Oxygenation Level Dependent) contrast MRI to assess tumor oxygenation and predict radiation response. Methods BOLD and TOLD MRI were performed on Dunning R3327-AT1 rat prostate tumors during hyperoxic gas breathing challenge at 4.7 T. Animals were divided into two groups. In Group 1 (n=9), subsequent 19F MRI based on spin lattice relaxation of hexafluorobenzene reporter molecule provided quantitative oximetry for comparison. For Group 2 rats (n=13) growth delay following a single dose of 30 Gy was compared with pre-irradiation BOLD and TOLD assessments. Results Oxygen (100%O2) and carbogen (CB; 95%O2/5%CO2) challenge elicited similar BOLD, TOLD and pO2 responses. Strong correlations were observed between BOLD or R2* response and quantitative 19F pO2 measurements. TOLD response showed a general trend with weaker correlation. Irradiation caused a significant tumor growth delay and tumors with larger changes in TOLD and R1 values upon oxygen breathing exhibited significantly increased tumor growth delay. Conclusion These results provide further insight into the relationships between oxygen sensitive (BOLD/TOLD) MRI and tumor pO2. Moreover, a larger increase in R1 response to hyperoxic gas challenge coincided with greater tumor growth delay following irradiation.

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R_{2}^{*}

, but effective studies of R 1 and

R_{2}^{*}

response to oxygen breathing have been reported recently in human tumors .…”

Section: Discussionmentioning

confidence: 99%

Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response

et al. 2013

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“…T 1 demonstrates sensitivity to dissolved oxygen, thereby acting as a potential T 1 -shortening paramagnetic contrast agent (19). An oxygen-induced increase in the R 1 has the potential to provide noninvasive measurements of fluctuations in the oxygen level of tissue, as a complement to BOLD imaging (30,31). Unfortunately, this technique is still hampered by insufficient sensitivity (only a few percentage changes) and the D R 1 measured may be biased owing to confounders unrelated to changes in the oxygen level in the tissue, such as an alteration in blood flow, and the H 2 O content of the tissue (32).…”

Section: Introductionmentioning

confidence: 99%

“…Hypoxic challenges were performed by the injection of the antivascular agent CA4, described to induce a vascular shutdown as early as 3 hours after the administration of the drug (36), whereas hypoxic challenges were induced by a carbogen breathing (95%O 2 /5%CO 2 ) known to acutely increase tumor oxygenation in a wide range of tumor models/xenografts and in human tumors (36)(37)(38)(39)(40)31). Oxygenation was assessed in matching tumors (the same tumors underwent both EPR and MRI experiments) using EPR oximetry as a method of reference for the quantitative assessment of the tumor pO 2 .…”

Section: Introductionmentioning

confidence: 99%

Qualification of a Noninvasive Magnetic Resonance Imaging Biomarker to Assess Tumor Oxygenation

Colliez

Neveu

Magat

et al. 2014

Clinical Cancer Research

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Purpose: Although hypoxia has been long recognized as a crucial factor impairing tumor response in many therapeutic schemes, atraumatic and reliable methods of individually quantifying tumor oxygenation are still lacking in day-to-day clinical practice. The aim of this work was to investigate the potentially quantitative properties of our recently described noninvasive magnetic resonance (MR) technique "MOBILE" (mapping of oxygen by imaging lipids relaxation enhancement) and to qualify this endogenous contrast as a tumor hypoxia marker.Experimental Design: The "MOBILE" technique, which assesses the longitudinal MR relaxation rate, R 1 , of lipid protons, was benchmarked with the parent technique which assesses the global (or water) R 1 , in response to a hyperoxic challenge (carbogen breathing) and to a hypoxic challenge (combretastatin A4) in MDA-MB-231 xenografts and in NT2 mammary tumors. Electron paramagnetic resonance (EPR) oximetry was used to quantitatively assess the tumor pO 2 in matching tumors longitudinally.Results and Conclusion: Our study evidenced that (i) positive and negative changes in tumor oxygenation can be detected using MOBILE; (ii) a change in the R 1 of lipids is positively correlated with a change in the tumor pO 2 (P ¼ 0.0217, r ¼ 0.5097); (iii) measured lipid R 1 values are positively correlated with absolute pO 2 values in both tumor models (P ¼ 0.0275, r ¼ 0.3726); and (iv) changes in the R 1 of lipids are more sensitive than changes in the global R 1 . As this technique presents unique translational properties, it seems promising for the individual longitudinal monitoring of tumor oxygenation in a clinical setting.

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“…A dynamic T1-weighted short TR steady-state spoiled multi-gradient-echo sequence (dSSPMGE) enables to map simultaneously changes in the relaxation rates R2* and R1 (dR2*, dR1) of normal and tumor tissue during inhalation of carbogen (Cb5) and 5 % carbon dioxide in air (CO 2 -air) [22]. The sequence dynamically measures dR2* and dR1 over a period of 7:52 min.…”

Section: Example 4: R1 and R2* Changes During Respiratory Challenges mentioning

confidence: 99%

“…Figure 4 displays T2-and T1-weighted images after contrast administration of a patient with a partially hemorrhagic glioblastoma (a). The dR2* and dR1 maps (b) assess the oxygenation and vasoreactivity of the tumor tissue during carbogen inhalation [22]. The tumor area (white arrow) shows a strong R2* and R1 decrease during carbogen inhalation consistent with low baseline oxygenation, mainly tive T1 (qT1) map depicts the tissue-specific longitudinal relaxation time (in ms) in each voxel.…”

Section: Example 4: R1 and R2* Changes During Respiratory Challenges mentioning

confidence: 99%

Quantitative MR Imaging of Brain Tissue and Brain Pathologies

et al. 2015

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Measurement of basic quantitative magnetic resonance (MR) parameters (e.g., relaxation times T1, T2*, T2 or respective rates R (1/T)) corrected for radiofrequency (RF) coil bias yields different conventional and new tissue contrasts as well as volumes for tissue segmentation. This approach also provides quantitative measures of microstructural and functional tissue changes. We herein demonstrate some prospects of quantitative MR imaging in neurological diagnostics and science.

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Dynamic and simultaneous MR measurement of R₁ and R₂* changes during respiratory challenges for the assessment of blood and tissue oxygenation

Cited by 19 publications

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Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response

Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response

Qualification of a Noninvasive Magnetic Resonance Imaging Biomarker to Assess Tumor Oxygenation

Quantitative MR Imaging of Brain Tissue and Brain Pathologies

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Dynamic and simultaneous MR measurement of R1 and R2* changes during respiratory challenges for the assessment of blood and tissue oxygenation

Cited by 19 publications

References 0 publications

Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response

Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response

Qualification of a Noninvasive Magnetic Resonance Imaging Biomarker to Assess Tumor Oxygenation

Quantitative MR Imaging of Brain Tissue and Brain Pathologies

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Product

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Dynamic and simultaneous MR measurement of R₁ and R₂* changes during respiratory challenges for the assessment of blood and tissue oxygenation

Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response

Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response