Dynamic Aspects of Gastric Emptying in Patients with Peptic Ulcer According to Ulcer Stages

Miyaoka, T.; Misaki, Fumio; Sasaki, Z; Kimoto, Kunihiko; Kawai, Keiichi

doi:10.1159/000198049

Cited by 4 publications

(1 citation statement)

References 4 publications

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“…Conversely, the distal stomach mixes gastric acid and food mass via periodic peristalsis to promote digestion, and then it breaks down solid food into 1- to 2-mm pieces and pushes them out through the pylorus 17 . However, controversy remains regarding the association between peptic ulcer location and the degree of alteration in emptying function 10 18 19 20 21 .…”

Section: Discussionmentioning

confidence: 99%

Change in gastric emptying eight weeks after endoscopic submucosal dissection in patients with early gastric cancer

et al. 2016

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Background: Gastric emptying after endoscopic submucosal dissection (ESD) for early gastric cancer is not clear. The aim of this study was to evaluate changes in gastric emptying from before ESD to 8 weeks after ESD. Methods: In total, 54 patients with early gastric cancer were enrolled in this study. A breath test with carbon 13 (13C) was conducted before ESD and at 1 and 8 weeks after ESD. The Tlag and T1/2 values were analyzed at each time point. The primary outcomes were the changes in the Tlag and T1/2 values from before ESD to 1 and 8 weeks after ESD. The secondary outcomes were the factors associated with the changes in the Tlag and T1/2 values. Results: Gastric emptying was delayed at 1 and 8 weeks after ESD compared with before ESD (Tlag P = 0.002, P < 0.001; T1/2 P = 0.005, P = 0.001, respectively). The changes in the Tlag and T1/2 values from before ESD to 1 week after ESD were greater for proximal stomach lesions than for distal stomach lesions (P = 0.028, P < 0.001). Proximal stomach lesions were identified as the significant factor that influenced changes in the Tlag and T1/2 values from before ESD to 1 week after ESD in the multivariate analyses (Tlag P = 0.003, T1/2 P = 0.005). Conclusions: ESD induced delayed gastric emptying until 8 weeks after ESD. Proximal stomach lesions were also associated with decreased emptying 1 week after ESD.

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Section: Discussionmentioning

confidence: 99%

Change in gastric emptying eight weeks after endoscopic submucosal dissection in patients with early gastric cancer

et al. 2016

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Is gastric emptying abnormal in duodenal ulcer?

et al. 1986

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To investigate the possibility that an abnormality of gastric emptying exists in duodenal ulcer and to determine if such an abnormality persists after ulcer healing, scintigraphic gastric emptying measurements were undertaken in 16 duodenal ulcer patients before, during, and after therapy with cimetidine; in 12 patients with pernicious anemia, and in 12 control subjects. No difference was detected in the rate or pattern of gastric emptying in duodenal ulcer patients before and after ulcer healing with cimetidine compared with controls, but emptying of the solid component of the test meal was more rapid during treatment with the drug. Comparison of emptying patterns obtained in duodenal ulcer subjects during and after cimetidine treatment with those obtained in pernicious anemia patients and controls revealed a similar relationship that was characterized by a tendency for reduction in the normal differentiation between the emptying of solid and liquid from the stomach. The similarity in emptying patterns in these groups of subjects suggests that gastric emptying of solids may be influenced by changes in the volume of gastric secretion. The failure to detect an abnormality of gastric emptying in duodenal ulcer subjects before and after ulcer healing calls into question the widespread belief that abnormally rapid gastric emptying is a feature with pathogenetic significance in duodenal ulcer disease.

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Biphasic effect of duodenal ulcerogens on gastric emptying in the rat

1988

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The effect of the duodenal ulcerogen cysteamine on gastric emptying of a liquid meal was compared to that of two newly identified duodenal ulcerogens, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and mepirizole. Emptying rates after acute and chronic treatment with duodenal ulcerogens were obtained. Acute administration of cysteamine, MPTP, or mepirizole significantly delayed gastric emptying of the meal. Chronically treated rats, however, showed either no change or accelerated gastric emptying after cysteamine, MPTP, or mepirizole. Gastric emptying in chronically treated animals was faster in rats that developed the most severe duodenal ulcers. These results indicate that delayed gastric emptying instead of accelerated emptying is a more common abnormality during duodenal ulceration. After the ulcer develops, however, unaltered or accelerated gastric emptying is observed experimentally, thus suggesting that accelerated gastric emptying in duodenal ulcers is an acquired alteration. The implications that these experimental findings may have in the pathogenesis of duodenal ulcer, in light of the clinical data available, are discussed.

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Dynamic Aspects of Gastric Emptying in Patients with Peptic Ulcer According to Ulcer Stages

Cited by 4 publications

References 4 publications

Change in gastric emptying eight weeks after endoscopic submucosal dissection in patients with early gastric cancer

Change in gastric emptying eight weeks after endoscopic submucosal dissection in patients with early gastric cancer

Is gastric emptying abnormal in duodenal ulcer?

Biphasic effect of duodenal ulcerogens on gastric emptying in the rat

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