2016
DOI: 10.1111/tri.12751
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Dynamic changes of B-cell compartments in kidney transplantation: lack of transitional B cells is associated with allograft rejection

Abstract: SUMMARYB cells play an important role in the immune responses which affect the outcomes of kidney allografts. Dynamic changes of B-cell compartments in clinical kidney transplantation are still poorly understood. B-cell subsets were prospectively monitored using flow cytometry for 1 year in 98 kidney transplant recipients. Data were correlated with immunosuppression and clinical outcomes. An increase in the total population of B lymphocytes was observed during the first week after transplantation. CD38high CD… Show more

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Cited by 44 publications
(43 citation statements)
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“…Their findings are complementary to and build on their previous work, and are consistent with other recent work examining transitional B cells in the early post-transplant period [8,9]. Of particular interest for future work will be understanding the dynamic changes in transitional cell subsets in individual patients and relating this to changes in eGFR, as well as understanding whether specific treatments influence the relationship between T1 and T2 subsets.…”
supporting
confidence: 71%
“…Their findings are complementary to and build on their previous work, and are consistent with other recent work examining transitional B cells in the early post-transplant period [8,9]. Of particular interest for future work will be understanding the dynamic changes in transitional cell subsets in individual patients and relating this to changes in eGFR, as well as understanding whether specific treatments influence the relationship between T1 and T2 subsets.…”
supporting
confidence: 71%
“…A possible beneficial consequence of the incomplete inhibition of B-cells by costimulation blockade is that belatacept favored the (potentially regulatory) IL-10 + transitional B-cell survival, while this was diminished by tacrolimus (3032). However, these findings were not confirmed by multivariable regression analyses.…”
Section: Discussionmentioning
confidence: 99%
“…Drawing on the correlation between kidney transplant tolerance and regulatory B cells, the prognostic value of pretransplantation transitional/regulatory B cells and transplantation outcome has been approached [48, 49]. In a prospective study, Shabir and colleagues show that only higher transitional B cell frequencies before transplantation, but not regulatory T cells, total B cells, or memory B cells, correlate with lower incidence of biopsy proven acute rejection [48].…”
Section: Potential Role Of Regulatory B Cells In Transplantationmentioning
confidence: 99%
“…In a prospective study, Shabir and colleagues show that only higher transitional B cell frequencies before transplantation, but not regulatory T cells, total B cells, or memory B cells, correlate with lower incidence of biopsy proven acute rejection [48]. Moreover, patients lacking transitional B cells three months after transplantation are at higher risk of suffering from both T cell and antibody mediated rejection [49]. …”
Section: Potential Role Of Regulatory B Cells In Transplantationmentioning
confidence: 99%