Dynamic Changes of Functional Neuronal Activities Between the Auditory Pathway and Limbic Systems Contribute to Noise-Induced Tinnitus with a Normal Audiogram

Qu, Tengfei; Qi, Yue; Yu, Sangjie; Du, Zhongtao; Wei, Wei; Cai, Aoling; Wang, Jie; Nie, Binbin; Liu, Ke; Gong, Shusheng

doi:10.1016/j.neuroscience.2019.03.054

Cited by 22 publications

(17 citation statements)

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“…The present study showed reduced connections between the STG and associative areas that constitute an emerging feature of brain architecture. Our finding demonstrates that the STG is the main cortical hub in the brain network that is affected by acute tinnitus with hearing loss, which is in line with the hypothesis that the dysconnectivity pattern of the STG is involved in tinnitus perception (Chen et al, 2017a;Qu et al, 2019;Berlot et al, 2020). The STG is regarded as a critical region which receives the neuronal projection from auditory pathway (Binder, 2017) and has been reported to be associated with cognitive functions including memory, auditory cognition and semantics (Jackson et al, 2018).…”

Section: Functional Connectivity and Spontaneous Brain Activation In supporting

confidence: 89%

“…In this study, reduced undirected connectivity between the AMYG and STG but an increased connectivity between the GCA from the AMYG to the STG was found. The AMYG is a vital part of the subcortical limbic structure, which receives and sends auditory information to the auditory cortex to relay emotional attributes (Yan, 2003;Keuroghlian and Knudsen, 2007;Qu et al, 2019;Xu et al, 2019). Furthermore, the AMYG not only receives information from auditory cortex, but also receives directed projection from subcortical areas of the ascending auditory pathway (Pannese et al, 2016).…”

Section: Functional Connectivity and Correlation Analysis In Limbic Smentioning

confidence: 99%

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Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss

Cai

Xie

et al. 2020

Front. Neurosci.

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The neural bases in acute tinnitus remains largely undetected. The objective of this study was to identify the alteration of the brain network involved in patients with acute tinnitus and hearing loss. Methods: Acute tinnitus patients (n = 24) with hearing loss and age-, sex-, education-matched healthy controls (n = 21) participated in the current study and underwent resting-state functional magnetic resonance imaging (fMRI) scanning. Regional homogeneity and amplitude of low-frequency fluctuation were used to investigate the local spontaneous neural activity and functional connectivity (FC), and Granger causality analysis (GCA) was used to analyze the undirected and directed connectivity of brain regions. Results: Compared with healthy subjects, acute tinnitus patients had a general reduction in FC between auditory and non-auditory brain regions. Based on FC analysis, the superior temporal gyrus (STG) revealed reduced undirected connectivity with nonauditory brain regions including the amygdala (AMYG), nucleus accumbens (NAc), the cerebellum, and postcentral gyrus (PoCG). Using the GCA algorithm, increased effective connectivity from the right AMYG to the right STG, and reduced connectivity from the right PoCG to the left NAc was observed in acute tinnitus patients with hearing loss. The pure-tone threshold was positively correlated with FC between the AMYG and STG, and negatively correlated with FC between the left NAc and the right PoCG. In addition, a negative association between the GCA value from the right PoCG to the left NAc and the THI scores was observed. Conclusion: Acute tinnitus patients have aberrant FC strength and causal connectivity in both the auditory and non-auditory cortex, especially in the STG, AMYG, and NAc. The current findings will provide a new perspective for understanding the neuropathophysiological mechanism in acute tinnitus.

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Section: Functional Connectivity and Spontaneous Brain Activation In supporting

confidence: 89%

Section: Functional Connectivity and Correlation Analysis In Limbic Smentioning

confidence: 99%

Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss

Cai

Xie

et al. 2020

Front. Neurosci.

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“…Our previous study showed that aberrant neural activity in the central auditory pathway is often accompanied by abnormal neural activity in the limbic system, especially in the hippocampus and amygdala. Therefore, it could have a functional connectivity between the central auditory pathway and the limbic system (Qu et al, 2019). It has been proposed that neuropsychiatric disorders may have social memory deficits, such as schizophrenia and autism (Meltzer et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Complete Elimination of Peripheral Auditory Input Before Onset of Hearing Causes Long-Lasting Impaired Social Memory in Mice

et al. 2021

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Hearing is one of the most important senses needed for survival, and its loss is an independent risk factor for dementia. Hearing loss (HL) can lead to communication difficulties, social isolation, and cognitive dysfunction. The hippocampus is a critical brain region being greatly involved in the formation of learning and memory and is critical not only for declarative memory but also for social memory. However, until today, whether HL can affect learning and memory is poorly understood. This study aimed to identify the relationship between HL and hippocampal-associated cognitive function. Mice with complete auditory input elimination before the onset of hearing were used as the animal model. They were first examined via auditory brainstem response (ABR) to confirm hearing elimination, and behavior estimations were applied to detect social memory capacity. We found significant impairment of social memory in mice with HL compared with the controls (p < 0.05); however, no significant differences were seen in the tests of novel object recognition, Morris water maze (MWM), and locomotion in the open field (p > 0.05). Therefore, our study firstly demonstrates that hearing input is required for the formation of social memory, and hearing stimuli play an important role in the development of normal cognitive ability.

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“…Observou-se o aumento do incômodo do zumbido proporcionalmente ao aumento da ansiedade, mesmo a maioria dos participantes tendo apresentando baixos níveis de ansiedade, conforme foi apontado em demais estudos 20 . Este fato ocorre em face dos indivíduos com zumbido apresentarem aumento da atividade neural no córtex auditivo esquerdo e uma diminuição da atividade neural no sistema límbico (hipocampo e amígdala), ocorrendo comunicação disfuncional entre estas regiões cerebrais 21 . Assim como, ocorre uma conectividade direcional do nucleus accumbens, no sistema límbico, para o córtex pré-frontal 9 comparar com a idade, não foi observada correlação significativa entre os níveis de ansiedade através do IDATE -Traço e a idade dos participantes do estudo (r=-0,080; p=0,526).…”

Section: Discussionunclassified

[Id 51714] Relação Da Ansiedade Com O Zumbido Crônico

Martins¹,

Carneiro²,

Ferreira³

et al. 2020

RBCS

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Objetivo: Investigar o nível de ansiedade em pacientes com queixa de zumbido e analisar a relação entre os dois fatores. Metodologia: Pesquisa do tipo estudo de campo, descritiva, transversal e observacional, com caráter quantitativo. A amostra foi composta por 65 indivíduos com queixa de zumbido, sendo 38 mulheres e 27 homens, com média de idades de 53,1 anos e 52,9 anos, respectivamente. Os critérios de elegibilidade foram ter mais de 18 anos e apresentar zumbido crônico. Todos os voluntários passaram por avaliação audiológica básica e realizaram acufenometria. Além disso, realizou-se a anamnese do zumbido e aplicou-se o Tinnitus Handicap Inventory, a Escala Visual Analógica e o Inventário de ansiedade traço e estado. Resultados: Observou-se um nível de ansiedade, predominantemente, baixo na amostra (50,7% IDATE–Traço e 76,9% IDATE–Estado). A intensidade do zumbido não teve relação com o grau de incômodo do som, nem com o nível de ansiedade. Em relação ao incômodo do zumbido, verificou-se que foi proporcional ao aumento da ansiedade traço. Ao dividir os grupos por sexo e por idade e compará-los com o incômodo do zumbido e com os valores do IDATE-Traço, foram encontrados resultados significativos, apenas, para o sexo feminino. Conclusão: Verificou-se uma relação entre o incômodo do zumbido e os níveis de ansiedade. Portanto, a ansiedade deverá ser investigada pelos profissionais que tratam indivíduos com queixa de zumbido, possibilitando a melhoria da qualidade de vida desta população.

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Dynamic Changes of Functional Neuronal Activities Between the Auditory Pathway and Limbic Systems Contribute to Noise-Induced Tinnitus with a Normal Audiogram

Cited by 22 publications

References 100 publications

Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss

Aberrant Functional and Causal Connectivity in Acute Tinnitus With Sensorineural Hearing Loss

Complete Elimination of Peripheral Auditory Input Before Onset of Hearing Causes Long-Lasting Impaired Social Memory in Mice

[Id 51714] Relação Da Ansiedade Com O Zumbido Crônico

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