Dynamic changes of serum SARS-CoV-2 antibody levels in COVID-19 patients

He, Lu; Zeng, Cheng; Xu, Wanzhou; Liu, Ying; Lin, Ren; Xie, Xinhui; Xia, Hongmiao; Tang, Shiqi; Xu, Lijuan; Chen, Changzheng

doi:10.1016/j.jinf.2022.04.032

Cited by 2 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This can be partially attributed to the relatively long interval between the onset of infection and the baseline visit (approximately 16 weeks). 28 Interestingly, in our study, 11 NI participants showed lower levels of IgG antibodies (<10 RU/mL) and corresponding lower NAb levels. Other studies have reported a similar rate of 9.6% of individuals with no antibody response after COVID-19.…”

Section: Discussioncontrasting

confidence: 42%

“…In this study, we did not observe significantly elevated levels of IgG at baseline visits in participants with prior infection. This can be partially attributed to the relatively long interval between the onset of infection and the baseline visit (approximately 16 weeks) 28 . Interestingly, in our study, 11 NI participants showed lower levels of IgG antibodies (<10 RU/mL) and corresponding lower NAb levels.…”

Section: Discussionmentioning

confidence: 48%

See 1 more Smart Citation

Ethno‐demographic disparities in humoral responses to the COVID‐19 vaccine among healthcare workers

Ahluwalia,

Vashisht,

Singh

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

The COVID‐19 pandemic had a profound impact on global health, but rapid vaccine administration resulted in a significant decline in morbidity and mortality rates worldwide. In this study, we sought to explore the temporal changes in the humoral immune response against SARS‐CoV‐2 healthcare workers (HCWs) in Augusta, GA, USA, and investigate any potential associations with ethno‐demographic features. Specifically, we aimed to compare the naturally infected individuals with naïve individuals to understand the immune response dynamics after SARS‐CoV‐2 vaccination. A total of 290 HCWs were included and assessed prospectively in this study. COVID status was determined using a saliva‐based COVID assay. Neutralizing antibody (NAb) levels were quantified using a chemiluminescent immunoassay system, and IgG levels were measured using an enzyme‐linked immunosorbent assay method. We examined the changes in antibody levels among participants using different statistical tests including logistic regression and multiple correspondence analysis. Our findings revealed a significant decline in NAb and IgG levels at 8−12 months postvaccination. Furthermore, a multivariable analysis indicated that this decline was more pronounced in White HCWs (odds ratio [OR] = 2.1, 95% confidence interval [CI] = 1.07−4.08, p = 0.02) and IgG (OR = 2.07, 95% CI = 1.04−4.11, p = 0.03) among the whole cohort. Booster doses significantly increased IgG and NAb levels, while a decline in antibody levels was observed in participants without booster doses at 12 months postvaccination. Our results highlight the importance of understanding the dynamics of immune response and the potential influence of demographic factors on waning immunity to SARS‐CoV‐2. In addition, our findings emphasize the value of booster doses to ensure durable immunity.

show abstract

Section: Discussioncontrasting

confidence: 42%

Section: Discussionmentioning

confidence: 48%

Ethno‐demographic disparities in humoral responses to the COVID‐19 vaccine among healthcare workers

Ahluwalia,

Vashisht,

Singh

et al. 2023

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…[ 35 ] However, the median time interval between the most recent vaccination and surgery in our cohort was 304 days, which exceeded the claimed 6-month window of protection. [ 36 , 37 ] The consensus recommendations indicated optimizing patients' immunity preoperatively with at least three doses and administering the final dose at least 2 weeks prior to surgery. [ 7 ] Regarding the effects of preoperative optimization on perioperative outcomes for patients at risk of Omicron variant infection, the implications of possible pre-interventions can also be a focus.…”

Section: Discussionmentioning

confidence: 99%

Changes in early postoperative outcomes and complications observed in a single center during the 2022 COVID-19 pandemic wave in China: A single-center ambispective cohort study

Wang

Zheng

Zhu

et al. 2023

Chinese Medical Journal

View full text Add to dashboard Cite

Background: Currently, the effect of the 2022 nationwide coronavirus disease 2019 (COVID-19) wave on the perioperative prognosis of surgical patients in China is unclear. Thus, we aimed to explore its influence on postoperative morbidity and mortality in surgical patients. Methods: An ambispective cohort study was conducted at Xijing Hospital, China. We collected 10-day time-series data from December 29 until January 7 for the 2018–2022 period. The primary outcome was major postoperative complications (Clavien–Dindo class III–V). The association between COVID-19 exposure and postoperative prognosis was explored by comparing consecutive 5-year data at the population level and by comparing patients with and without COVID-19 exposure at the patient level. Results: The entire cohort consisted of 3350 patients (age: 48.5 ± 19.2 years), including 1759 females (52.5%). Overall, 961 (28.7%) underwent emergency surgery, and 553 (16.5%) had COVID-19 exposure (from the 2022 cohort). At the population level, major postoperative complications occurred in 5.9% (42/707), 5.7% (53/935), 5.1% (46/901), 9.4% (11/117), and 22.0% (152/690) patients in the 2018–2022 cohorts, respectively. After adjusting for potential confounding factors, the 2022 cohort (80% patients with COVID-19 history) had a significantly higher postoperative major complication risk than did the 2018 cohort (adjusted risk difference [aRD], 14.9% (95% confidence interval [CI], 11.5–18.4%); adjusted odds ratio [aOR], 8.19 (95% CI, 5.24–12.81)). At the patient level, the incidence of major postoperative complications was significantly greater in patients with (24.6%, 136/553) than that in patients without COVID-19 history (6.0% [168/2797]; aRD, 17.8% [95% CI, 13.6–22.1%]; aOR, 7.89 [95% CI, 5.76–10.83]). Secondary outcomes of postoperative pulmonary complications were consistent with primary findings. These findings were verified through sensitivity analyses using time-series data projections and propensity score matching. Conclusion: Based on a single-center observation, patients with recent COVID-19 exposure were likely to have a high incidence of major postoperative complications. Registration: NCT05677815 at https://clinicaltrials.gov/.

show abstract

Dynamic changes of serum SARS-CoV-2 antibody levels in COVID-19 patients

Cited by 2 publications

References 10 publications

Ethno‐demographic disparities in humoral responses to the COVID‐19 vaccine among healthcare workers

Ethno‐demographic disparities in humoral responses to the COVID‐19 vaccine among healthcare workers

Changes in early postoperative outcomes and complications observed in a single center during the 2022 COVID-19 pandemic wave in China: A single-center ambispective cohort study

Contact Info

Product

Resources

About