A pumped storage unit is a crucial guarantee in the pursuit of increased clean energy, especially in the progressively severe circumstances of low energy utilization and poor coordination of the integration of volatile renewable energy. However, due to their bidirectional operation design, pumped turbines possess an S-characteristic attribution, wherein the unsteady phenomena of unit vibration, pressure pulsation, and cavitation erosion happen during the start-up process and greatly impact the stable connection to the power grid. Therefore, a systematic study concentrating on an optimal unified paradigm of a start-up strategy for a pumped storage plant is conducted. Model construction, effective analysis, controller design, and collaborative optimization are sequentially expounded. Firstly, a refined start-up nonlinear model of a pumped storage plant with complex boundary conditions is constructed, wherein the delay time of frequency measurement, saturation, and dead zone features are comprehensively taken account. Furthermore, a variable universe fuzzy PID controller and its operation laws are proposed and specifically designed for the speed governing system of the pumped storage plant; the control quality and anti-disturbance performance are verified by a no-load frequency disturbance experiment. On this basis, taking speed overshoot for stationarity and speed rising time for rapidity, a novel open–close loop collaborative fuzzy control strategy is proposed with rotational speed feedback and a variable universe fuzzy PID control. The experiment results show that the proposed unified paradigm has better control performance in various performance indexes, and more balanced control quality and dynamic performance under various complex start-up conditions, which has great application value for ensuring the unit’s timely response to the power grid regulation task and improving the operating stability of the power system.