Virtual reality (VR) technologies allow for the creation of 3D environments that can be exploited at the human level, maximizing humans’ use of perceptual skills through their sensory channels, and enabling them to actively influence the course of events that take place in the virtual environment (VE). As such, they constitute a significant asset in the treatment of post-traumatic stress disorder (PTSD) via exposure therapy. In this article, we review the VR tools that have been developed to date for the treatment of PTSD. The article aims to analyze how VR technologies can be exploited from a sensorimotor and interactive perspective. The findings from this analysis suggest a significant emphasis on sensory stimulation to the detriment of interaction. Finally, we propose new ideas regarding the more successful integration of sensorimotor activities and interaction into VR exposure therapy for PTSD.