In this study, an unknown input observer is proposed for a class of nonlinear GPFOSs. For this class of systems, both full-order and reduced-order observers have been established. The investigated system satisfies the one-sided Lipschitz nonlinear condition, which is an improvement of the classic Lipschitz condition. Sufficient conditions have been proposed to ensure the error dynamics’ Mittag–Leffler stability. The value of this work lies in the fact that, to the best of the authors’ knowledge, this is the first research work that investigates the issue of Observer Design (OD) for GPFOSs. To exemplify the usefulness of the suggested observers, an illustrative numerical example is suggested.