Dynamic enhancement of upper abdominal organs in normal volunteers with MRI and effects of contrast dose reduction

Coche, Edgard; Bret, Patrice M.; Reinhold, Caroline

doi:10.1007/s002619900573

Cited by 2 publications

(2 citation statements)

References 11 publications

(16 reference statements)

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“…The contrast‐enhancement techniques used for these investigations relied on slower image acquisitions and did not utilize a timing bolus sequence. Recently, Coche et al (19) used a fast single section gradient‐echo technique with multiple acquisitions over 118 seconds, showing a mean time to maximum pancreatic enhancement of less than 25 seconds. We used a three‐dimensional fast GRE sequence, covering the whole pancreas in about 20 seconds, during suspended respiration.…”

Section: Discussionmentioning

confidence: 99%

Suspected early or mild chronic pancreatitis: Enhancement patterns on gadolinium chelate dynamic MRI

Zhang

Shi

Parker

et al. 2002

Magnetic Resonance Imaging

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Purpose: To assess whether measuring the pattern of pancreatic enhancement on gadolinium chelate dynamic magnetic resonance imaging (MRI) is helpful for diagnosis of suspected early or mild chronic pancreatitis. Materials and Methods:In this retrospective study, 24 patients with suspected early or mild chronic pancreatitis, classified by imaging criteria of equivocal chronic pancreatitis (ultrasound, computed tomography [CT] or ERCP) grading, had dynamic MRI that included unenhanced, arterial dominant, early venous, and late venous phases of contrast enhancement. Twenty patients without pancreatic diseases also had the dynamic sequence as a control group. The signal intensity was measured at the pancreatic head, body, and tail on all phases, and for each, the signal intensity ratio (SIR, the signal intensity in postcontrast divided by that in precontrast) was calculated. Two radiologists independently reviewed the images of the patients with suspected early or mild chronic pancreatitis for pancreatic morphologic abnormalities without knowing the results of signal intensity measurements.Results: On unenhanced images, there was no significant difference of signal intensity between control and pancreatitis groups (P Ͻ 0.05). In the pancreatitis group, but not in the control group, the unenhanced signal intensity of the pancreatic head and body were significantly higher than that of the tail (P Ͻ 0.05). In the control group, the greatest enhancement (highest SIR) after injection was in the arterial phase (1.89 Ϯ 0.31), significantly higher than that in the early venous phase (1.68 Ϯ 0.17, P Ͻ 0.01) and in the late venous phase (1.61 Ϯ 0.15, P Ͻ 0.001). The pancreatitis group, however, had an arterial phase SIR (1.65 Ϯ 0.23) that was significantly lower than its early venous phase SIR (1.75 Ϯ 0.22, P Ͻ 0.05) and lower than the arterial phase SIR of the control group (P Ͻ 0.01). The presence of an SIR less than 1.73 in the arterial phase and/or a delayed peak enhancement after contrast agent administration had a sensitivity and specificity of diagnosing early or mild chronic pancreatitis of 92% and 75%, respectively. This sensitivity was significantly higher than the sensitivity of 50% for diagnosis based on morphologic abnormalities (P Ͻ 0.05). Conclusion:Measuring pancreatic signal intensity on gadolinium chelate dynamic MRI is helpful for diagnosing early or mild chronic pancreatitis, especially before apparent pancreatic morphologic or signal intensity changes are present.

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