Dynamic Light Scattering

Merkus, Henk G.

doi:10.1007/978-1-4020-9016-5_12

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…where k represents the Boltzmann coefficient, T is the absolute temperature, η is the absolutely zero-shear viscosity of the medium used for NP dispersion, and d stands for the hydrodynamic diameter of the particle [86]. Tauer et al [87] utilized DLS to observe a decrease in diameter of PNIPAAm-based microgels by about 200 nm with changes in temperature.…”

Section: Dynamic Light Scattering and Zeta Potentialmentioning

confidence: 99%

Development and Characterization of Stimulus-Sensitive Nano/Microparticles for Medical Applications

Menon

Nguyen

2016

Handbook of Nanoparticles

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Section: Dynamic Light Scattering and Zeta Potentialmentioning

confidence: 99%

Development and Characterization of Stimulus-Sensitive Nano/Microparticles for Medical Applications

Menon

Nguyen

2016

Handbook of Nanoparticles

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“…In addition, larger particles may settle out of the measurement zone. Hence, these factors limit capability for measuring particle sizes above 3 m [89]. Laser Diffraction (LD) is typically used to measure particle size range of 0.05-80 m up to 2000 m. This technique can also be used to detect and quantify particle size ranges during the production procedure [56,88].…”

Section: Nanosuspension Characterisationmentioning

confidence: 99%

Nanosuspension Technologies for Delivery of Poorly Soluble Drugs

Yadollahi

Vasilev

Simović

2015

Journal of Nanomaterials

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Poor aqueous solubility of some drug molecules is a major problem in drug formulation. Drug nanosuspensions emerged as one solution to delivering such hydrophobic drugs. Scaling down to nanoparticles enhances drug aqueous solubility and bioavailability by increasing drug surface area that comes into contact with biological media. Nanosuspensions that have attracted particular attention are those sterically stabilised by steric polymers such as polyethylene glycol (PEG) with a typical size range of 10–100 nm. These nanoparticles are capable of accumulating in targeted areas such as cancer tissues and infarct zones with minimal damage to healthy tissues. Nanosuspensions are often prepared by commercially available methods such as high pressure homogenization, media milling, emulsification, and melt emulsification. Solidification and surface modification methods are post-processing techniques used to add particular properties for advanced therapies. In this review, we firstly describe preparation methods for nanosuspensions. Secondly, we highlight typical characterization techniques. Finally, we describe several practical application of applications for drug delivery design and different administration routes such as parenteral, pulmonary, oral, and ocular.

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