In packed fractionation, the liquid phase can be forced to become continuous, and the vapor phase dispersed, realizing emulsification regime. The paper presents the efficiency comparing results of packed fractionation with respect to the fractionation in an empty flooded column, as well as the influence of the heat flux and of the temperature inside the column's jacket. Experiments for determining the boiling heat transfer of the different methanol-ethanol concentration mixtures were performed. The variation of the boiling heat transfer coefficient at different concentrations of methanol-ethanol mixtures has a minimum, corresponding to the maximum of the difference between concentrations of vapor phase in equilibrium with the liquid phase.