Dynamic monitoring of circulating microRNAs as a predictive biomarker for the diagnosis and recurrence of papillary thyroid carcinoma

Zhang, Yanqing; Xu, Desheng; Pan, Jiaqi; Yang, Zhengyan; Chen, Meijun; Han, Jun; Zhang, Sijia; Sun, Lulu; Qiao, Hong

doi:10.3892/ol.2017.6028

Cited by 40 publications

(65 citation statements)

References 70 publications

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“…In addition, similar to previous reports (18,45,(66)(67)(68) our results indicated that the expression levels of miR-222 and miR-221 are significantly increased in serum from III/IV stage PTMC cases. A previous study suggested that both miR-222 and miR-221 are clustered on the X chromosome, and it is likely that they are encoded by a single polycistron, as was previously suggested (69).…”

Section: Discussionsupporting

confidence: 92%

“…miRNAs can be isolated from serum or plasma, and they can be used to detect many types of cancers (39)(40)(41). However, the promising use of miRNAs as biomarkers for PTC has been reported in only a few studies (28,35,(42)(43)(44)(45). To date, no studies have examined circulating miRNA expression in PTMC patients, and none have attempted to use serum miRNAs to analyze their association with the clinicopathologic features of PTMC.…”

Section: Discussionmentioning

confidence: 99%

“…To date, no studies have examined circulating miRNA expression in PTMC patients, and none have attempted to use serum miRNAs to analyze their association with the clinicopathologic features of PTMC. Although a few previous studies have demonstrated that circulating let-7e, miR-222, miR-221, miR-146b, miR-151-5p, miR-190 and miR-95 are overexpressed in PTC compared with benign thyroid nodules and healthy controls and offered a promising method for preoperative diagnosis of PTC, there is controversy and unresolved issues involving these studies (28,35,(42)(43)(44)(45). Firstly, different expression levels of the target miRNAs were noted in these various studies.…”

Section: Discussionmentioning

confidence: 99%

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Combination of serum microRNAs and ultrasound profile as predictive biomarkers of diagnosis and prognosis for papillary thyroid microcarcinoma

Zhang

Pan

et al. 2018

Oncol Rep

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Circulating microRNAs (miRNAs) are promising diagnostic markers in various types of cancers, including papillary thyroid carcinoma (PTC). However, there is sparse information reported with regards to miRNA expression in papillary thyroid microcarcinoma (PTMC) or concerning the role of a combination of miRNAs and ultrasound (US) in the diagnosis of PTMC before surgery. Therefore, we designed a study that aimed to evaluate miRNA expression levels and their potential associations with US findings and determine whether miRNAs could be used as diagnostic and prognostic biomarkers of PTMC. miR-222, miR-221, miR-146b and miR-21 levels were determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in serum from 58 patients with PTMC and 47 with PTC, 35 patients with benign thyroid nodules (BTN) and 40 control subjects. Expression levels of the four miRNAs in serum were evaluated before and after surgery. The results indicated that miR-222, miR-221, miR-146b and miR-21 expression levels were higher in the PTMC samples than in those from the BTN and control groups and the combination of miRNAs and US had a high sensitivity and specificity for discrimination between BTN and PTMC by receiver operating characteristic (ROC) curve analysis and improved the accuracy of diagnosis of PTMC before surgery. In addition, serum miRNA expression levels were significantly related to poor prognostic factors including metastatic lymph nodules (MLNs), multifocal and bilateral lesions, advanced stage and high-risk PTMC patients. The miRNA expression levels in serum from PTMC patients were rapidly reduced after surgery compared with levels before surgery. In addition, we also analyzed the miRNA expression levels in serum from patients who were divided into two groups according to factors indicating a good or poor prognosis associated with PTMC after surgery. The results suggested that after surgery, the miR-222, miR-146b and miR-21 expression levels were significantly higher in the poor prognosis group compared with these levels in the good prognosis group. Serum miRNA expression levels helped distinguish between benign and malignant nodules and were associated with a poor prognosis in PTMC. Circulating miRNAs may be useful as follow-up biomarkers and as diagnostic and prognostic tools.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Combination of serum microRNAs and ultrasound profile as predictive biomarkers of diagnosis and prognosis for papillary thyroid microcarcinoma

Zhang

Pan

et al. 2018

Oncol Rep

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“…Several countries were included in the 9 included articles: 7 focused China, one each from Korea 12 and Iran 13 . Seven articles used benign thyroid nodule (BTN) patients as controls, and two articles 14,15 using both BTN patients and healthy people as controls. One article 16 studied papillary thyroid micro carcinoma (PTMC) patients, and other eight articles studied PTC patients.…”

Section: Resultsmentioning

confidence: 99%

Diagnostic value of circulating microRNAs in thyroid carcinoma: A systematic review and meta‐analysis

Tian

Zhou

et al. 2020

Clinical Endocrinology

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Background and objective Thyroid cancer (TC) is the most common endocrine system tumour. Several studies had revealed the potential of circulating microRNAs (miRNAs) as novel biomarkers for the diagnosis of TC. The purpose of this meta‐analysis is to summarize published studies and evaluate the diagnostic accuracy of circulating miRNAs in TC detection. Methods In this meta‐analysis, we systematically searched three databases: PubMed, EMBASE and Cochrane Library. We used the bivariate mixed‐effects regression model to calculate the pooled diagnostic parameters and conduct the summary receiver operator characteristic curve (SROC). All calculations were performed using stata software. Results Thirty‐five studies from 9 articles, including 663 TC patients, 519 patients with benign thyroid nodules (BTNs), and 84 healthy controls were included in this meta‐analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR) and area under the SROC curve (AUC) were 0.81 (95% CI 0.75‐0.86), 0.81 (95% CI 0.75‐0.86), 4.3 (95% CI 3.2‐5.6), 0.24 (95% CI 0.18‐0.31), 18 (95% CI 12‐28) and 0.88 (95% CI 0.85‐0.90), respectively in BTN controls, and 0.81 (95% CI 0.75‐0.86), 0.85 (95% CI 0.75‐0.91), 5.3 (95% CI 3.3‐8.7), 0.23 (95% CI 0.18‐0.29), 24 (95% CI 14‐39), 0.89 (95% CI 0.86‐0.91) in healthy controls. The subgroup analysis found that multiple miRNA assays had higher diagnostic accuracy than single miRNA assays with sensitivity of 0.88, specificity of 0.89 and AUC of 0.94. Conclusion Circulating miRNAs have good values to diagnose TC and distinguish TC patients from BTN patients. MiRNAs can assist in the diagnosis of malignancy and avoid unnecessary surgery. In summary, circulating miRNAs should be added to our current clinical tools.

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“…9 ), preoperative thyroglobulin antibodies as potential marker for PTC in patients with indeterminate thyroid nodules 10 , serum SERPINE2/Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor (SLPI) concentrations as preoperative PTC biomarkers 11 , circulating miRNAs as a non-invasive biomarker for the diagnosis of PTC (ref. 12 ) and preoperative serum thyroglobulin (Tg) and changes in serum Tg during thyroid stimulating hormone (TSH) suppression as independent predictors of FTC in thyroid nodules with a cytological diagnosis of follicular lesion 13 . Nevertheless, continuous search for specific growth factors involved in the pathogenesis and progression of differentiated and anaplastic thyroid cancers still remains of utmost importance for improving preoperative diagnostics and for designing new therapeutic approaches to dealing with TC.…”

Section: Introductionmentioning

confidence: 99%

Elevated serum concentrations of IGF-1 and IGF-1R in patients with thyroid cancers

Ławnicka

Motylewska

Borkowska

et al. 2020

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. The rising incidence of thyroid cancer observed in the last few decades requires an improvement in diagnostic tools and management techniques for patients with thyroid nodules. Aims. The aim of this study was to assess serum concentrations of IGF-1 and IGF-1R in patients diagnosed with thyroid cancers. Methods. 36 patients diagnosed with papillary thyroid cancer (PTC), 11 subjects with follicular thyroid cancer (FTC), 9 patients with anaplastic thyroid cancer (ATC) and 19 subjects with multinodular nontoxic goiter (MNG) were enrolled to the study. The control group (CG) consisted of 20 healthy volunteers. Blood samples were collected one day before surgery. Serum IGF-1 and IGF-1R concentrations were measured using specific ELISA methods. Results. Significantly higher concentrations of IGF-1 were found in patients with PTC as compared with controls but not that obtained from subjects diagnosed with MNG. The concentration of IGF-1R was significantly elevated in subjects with PTC and ATC as compared with healthy volunteers. Similarly, patients diagnosed with PTC or ATC presented significantly higher serum concentration of IGF-1R in comparison to the MNG group. Conclusions. Our results show that the IGF-1-IGF-1R axis plays a significant role in the development of PTC and ATC and imply that serum concentrations of both cytokines may be considered as additional markers for the differentiation of malignancies during the preoperative diagnosis of patients with thyroid gland tumors. These results indicate that IGF-1R serum concentrations allow us to differentiate between MNG and PTC or ATC. Moreover IGF-1R serum values appear to be better predictor of PTC and ATC than IGF-1 concentrations.

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Dynamic monitoring of circulating microRNAs as a predictive biomarker for the diagnosis and recurrence of papillary thyroid carcinoma

Cited by 40 publications

References 70 publications

Combination of serum microRNAs and ultrasound profile as predictive biomarkers of diagnosis and prognosis for papillary thyroid microcarcinoma

Combination of serum microRNAs and ultrasound profile as predictive biomarkers of diagnosis and prognosis for papillary thyroid microcarcinoma

Diagnostic value of circulating microRNAs in thyroid carcinoma: A systematic review and meta‐analysis

Elevated serum concentrations of IGF-1 and IGF-1R in patients with thyroid cancers

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