The field of laser-matter interaction traditionally deals with the response of atoms, molecules and plasmas to an external light wave. However, the recent sustained technological progress is opening up the possibility of employing intense laser radiation to trigger or substantially influence physical processes beyond atomic-physics energy scales. Available optical laser intensities exceeding 10 22 W/cm 2 can push the fundamental lightelectron interaction to the extreme limit where radiation-reaction effects dominate the electron dynamics, can shed light on the structure of the quantum vacuum, and can trigger the creation of particles like electrons, muons and pions and their corresponding antiparticles. Also, novel sources of intense coherent high-energy photons and laserbased particle colliders can pave the way to nuclear quantum optics and may even allow for potential discovery of new particles beyond the Standard Model. These are the main topics of the present article, which is devoted to a review of recent investigations on high-energy processes within the realm of relativistic quantum dynamics, quantum electrodynamics, nuclear and particle physics, occurring in extremely intense laser fields.