Dynamic radiographic results of different semi-rigid lumbar fusion devices for degenerative lumbar spondylolisthesis: &amp;#8220;dynamic rod&amp;#8221; vs. &amp;#8220;dynamic screw head&amp;#8221;

Yang, Jin Seo; Cho, Yong Jun; Kang, Suk Hyung; Choi, Hyuk Jai

doi:10.5137/1019-5149.jtn.9784-13.1

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…How to overcome the shortcomings of rigid fixation with pedicle screws, maintain the stability of the spine while preserving the physiologic function of a fused segment part, and reduce the incidence of ASD has become a major focus of research interest [ 3 , 6 ]. In recent years, new techniques and methods, such as non-fusion fixation of the spine [ 7 , 8 ], minimally invasive endoscopic surgery of the spine [ 9 , 10 ], and artificial disk replacement, have been introduced [ 11 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Establishment of an animal model of adjacent segment degeneration after interbody fusion and related experimental studies

Chen,

Suo,

Xie

et al. 2023

J Orthop Surg Res

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Background Degenerative spine conditions are common and frequent clinical diseases, and adjacent segment disease (ASD) after spinal fusion (SF) is a common complication after spinal fusion (SF). In this study, we established an animal model of ASD after interbody fusion to observe the morphologic changes of adjacent segment (AS) disks and to determine the expression and significance of tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β) in ASD tissues to provide a good experimental basis and reference for clinical prevention and treatment of ASD after interbody fusion. Methods Thirty-six male and female New Zealand rabbits weighing 2.0–2.5 kg were randomly divided into control group (group A) and experimental groups (groups B, C, and D), with 9 rabbits in each group, of which groups B, C, and D were the 4-, 8-, and 12-week groups, respectively. Autologous iliac bone grafts were used as the bone graft material. In the experimental groups, a SF was performed on the C2–C3 intervertebral space. The C3–4 adjacent segments were examined. In the experimental group, the animals were subjected to gross observation, X-ray examination, hand touch inspection, and micro-computed tomography (micro-CT) 4, 8, and 12 weeks after surgery. The micromorphologic changes of the cervical disks in the segments of the control group and experimental groups were observed under light microscopy. Immunohistochemistry and Western blotting were used to detect the expression of TNF-α and IL-1β in the AS tissues after interbody fusion in the control and experimental groups. Results The measurement data of the rabbit cervical spine bony structures indicated that the length of the vertebral body and the sagittal diameter of the lower end of the vertebral body decreased gradually from the 2nd–6th cervical vertebrae, and the difference was statistically significant (P < 0.05). The difference in the transverse diameter of the lower end of the vertebral body was not statistically significant (P > 0.05), the change in the oblique diameter of the lower end of the vertebral body fluctuated, and the difference was statistically significant (P < 0.05). The fusion rate of the cervical spine by hand touch inspection was 22.2% (2/9), 55.6% (5/9), and 88.9% (8/9) in groups B, C, and D, respectively. The differences in bone volume-to-total volume (BV/TV) and X-ray scores were statistically significant in groups B, C, and D (P < 0.05). Significant degeneration occurred in groups B, C, and D compared with group A. The expression of TNF-α and IL-1β in the intervertebral disk tissue was significantly higher in groups B, C, and D compared with group A (P < 0.05), and increased with time. Conclusion In this study, an animal model of ASD after interbody fusion fixation in rabbits was successfully established. Postoperative imaging and hand touch inspection showed a positive correlation between the amount of new intervertebral bone and the degree of fusion with time. The results of immunohistochemistry and Western blot showed that TNF-α and IL-1β were highly expressed in the AS tissues of the experimental group after interbody fusion, and the degree of disk degeneration was positively correlated with the time after interbody fusion.

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Section: Introductionmentioning

confidence: 99%

Establishment of an animal model of adjacent segment degeneration after interbody fusion and related experimental studies

Chen,

Suo,

Xie

et al. 2023

J Orthop Surg Res

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“…More specifically, x-ray-based diagnostic imaging techniques measuring human inter-vertebral displacements have focused mostly on imaging the spine at static end-of-range positions [ 32 – 40 ]. However, qualitative and quantitative assessments of spinal motion have been enhanced by quantitative radiographic techniques that track displacements of pre-assigned coordinate points of specific anatomic locations on orthographic spinal images and by real-time joint-motion evaluation with XROMM-like techniques (using CT/magnetic-resonance-imaging-based 3-D models) and RSA (with per-operative implanted vertebral markers) in human subjects [ 22 , 28 , 38 , 41 – 47 ]. Regrettably, these approaches still require exposure to ionizing radiation and, at times, require marker implantation on the bones.…”

Section: Introductionmentioning

confidence: 99%

Development of a morphology-based modeling technique for tracking solid-body displacements: examining the reliability of a potential MRI-only approach for joint kinematics assessment

et al. 2016

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BackgroundSingle or biplanar video radiography and Roentgen stereophotogrammetry (RSA) techniques used for the assessment of in-vivo joint kinematics involves application of ionizing radiation, which is a limitation for clinical research involving human subjects. To overcome this limitation, our long-term goal is to develop a magnetic resonance imaging (MRI)-only, three dimensional (3-D) modeling technique that permits dynamic imaging of joint motion in humans. Here, we present our initial findings, as well as reliability data, for an MRI-only protocol and modeling technique.MethodsWe developed a morphology-based motion-analysis technique that uses MRI of custom-built solid-body objects to animate and quantify experimental displacements between them. The technique involved four major steps. First, the imaging volume was calibrated using a custom-built grid. Second, 3-D models were segmented from axial scans of two custom-built solid-body cubes. Third, these cubes were positioned at pre-determined relative displacements (translation and rotation) in the magnetic resonance coil and scanned with a T1 and a fast contrast-enhanced pulse sequences. The digital imaging and communications in medicine (DICOM) images were then processed for animation. The fourth step involved importing these processed images into an animation software, where they were displayed as background scenes. In the same step, 3-D models of the cubes were imported into the animation software, where the user manipulated the models to match their outlines in the scene (rotoscoping) and registered the models into an anatomical joint system. Measurements of displacements obtained from two different rotoscoping sessions were tested for reliability using coefficient of variations (CV), intraclass correlation coefficients (ICC), Bland-Altman plots, and Limits of Agreement analyses.ResultsBetween-session reliability was high for both the T1 and the contrast-enhanced sequences. Specifically, the average CVs for translation were 4.31 % and 5.26 % for the two pulse sequences, respectively, while the ICCs were 0.99 for both. For rotation measures, the CVs were 3.19 % and 2.44 % for the two pulse sequences with the ICCs being 0.98 and 0.97, respectively. A novel biplanar imaging approach also yielded high reliability with mean CVs of 2.66 % and 3.39 % for translation in the x- and z-planes, respectively, and ICCs of 0.97 in both planes.ConclusionsThis work provides basic proof-of-concept for a reliable marker-less non-ionizing-radiation-based quasi-dynamic motion quantification technique that can potentially be developed into a tool for real-time joint kinematics analysis.

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Preliminary Comparison of Assessment Methods for the Trunk Flexion-Extension Movement in the Lumbar Vertebrae Instability Patient

Amici

Piovanelli

Ragni

et al. 2021

Human Interaction, Emerging Technologies and Future Systems V

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Dynamic radiographic results of different semi-rigid lumbar fusion devices for degenerative lumbar spondylolisthesis: “dynamic rod” vs. “dynamic screw head”

Abstract: These outcomes may play a role in decreasing the risk of ASD after dynamic stabilization, at least 2 years after surgery.

Cited by 4 publications

References 18 publications

Establishment of an animal model of adjacent segment degeneration after interbody fusion and related experimental studies

Establishment of an animal model of adjacent segment degeneration after interbody fusion and related experimental studies

Development of a morphology-based modeling technique for tracking solid-body displacements: examining the reliability of a potential MRI-only approach for joint kinematics assessment

Preliminary Comparison of Assessment Methods for the Trunk Flexion-Extension Movement in the Lumbar Vertebrae Instability Patient

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