In order to investigate explosive properties of ethylene-air premixed gas in flameproof enclosure with interconnected structure under pressure piling, a 161.5 mm × 161.5 mm × 250 mm cylindrical flameproof enclosure and a 161.5 mm × 161.5 mm × 500 mm cylindrical flameproof enclosure connected by a partition with a hole (inner diameter of 15 mm) were studied. A mathematical model of the fluid dynamics combustion reaction was selected to perform numerical simulations of this structure using the finite volume method. Numerical simulations revealed that under pressure piling, the maximum explosion pressure in Cavity B was significantly higher than that in Cavity A; the maximum rate of explosion pressure rise in Cavity B was significantly higher than that in Cavity A; combustion rate of combustible gas in Cavity B was much higher than that in Cavity A. Results of the study have practical and theoretical significance for the design and installation of flameproof enclosures.