In this contribution, the dynamic response of two railway bridges, represented by a viscoelastically supported Euler-Bernoulli model, subjected to high-speed trains is analyzed and discussed. Different types of high-speed trains are considered, which are modeled as moving mass-spring-damper (MSD) system. The structural response is determined by a dynamic substructuring approach, in which the equation of motion of the beam bridge model and the equations of motion of the MSD system, both written in state space, are coupled using a generalized corresponding assumption. The coupled set of equations of motion representing the dynamic soil-structure-vehicle interaction model are solved by time history analysis. The utilized approach captures all essential features of dynamic soil-structure-vehicle interaction and allows for a numerically efficient evaluation of the dynamic responses of the structure. Particular attention is paid to the influence of the MSD system on the beam bridge during approach and after departure. The structural response of the considered beam bridges is compared and discussed for the different types of high-speed trains and different subsoil conditions.