Based on single-phase medium theory and unsaturated porous medium theory, the vibration isolation effect of setting a single-phase solid wave impeding block (WIB) in the unsaturated soil foundation under an underground dynamic load is investigated. Using the Fourier integral transform and Helmholtz vector decomposition, the calculation formula of the dynamic response of unsaturated soil foundation under an underground dynamic load is established by combining the boundary conditions. The influence of physical and mechanical parameters such as saturation, load frequency, embedded depth of WIB, thickness of WIB, and elastic modulus of WIB on the vibration isolation performance in unsaturated soil foundation is analyzed. The results show that in the case of underground dynamic load, setting a WIB in unsaturated soil foundation could achieve a better vibration isolation effect. The surface displacement amplitude decreases significantly with the increase of saturation, load frequency, embedded depth, thickness, and elastic modulus of WIB.