A quasi-Z-source inverter (qZSI) is a single-stage inverter that enables a boost of the input dc voltage through the utilization of a so-called shoot-through state (STS). Generally, the efficiency of the qZSI depends on the utilized STS injection method to a significant extent. This paper presents a novel method of STS injection, called the zero-sync method, in which the STS occurrence is synchronized with the beginning of the zero switching states (ZSSs) of the three-phase sinusoidal pulse width modulation (SPWM). In this way, compared to the conventional STS injection method, the total number of switchings per transistor is reduced. The ZSSs are detected by utilizing the SPWM pulses and the logic OR gates. The desired duration of the STS is implemented by utilizing the LM555CN timer. The laboratory setup of the three-phase qZSI in the stand-alone operation mode was built to compare the proposed zero-sync method with the conventional STS injection method. The comparison was carried out for different values of the switching frequency, input voltage, duty ratio, and load power. As a result of the implementation of the zero-sync method, the qZSI efficiency was increased by up to 4%. In addition, the unintended STSs, caused by the non-ideal switching dynamics of the involved transistors, were successfully eliminated by introducing the optimal dead-time as part of the modified zero-sync method. As a result, the efficiency was increased by up to 12% with regard to the conventional method.