In this paper, the dynamic behaviour of the stage-structure prey-predator fractional-order derivative system is considered and discussed. In this model, the Crowley–Martin functional response describes the interaction between mature preys with a predator. The existence, uniqueness, non-negativity, and the boundedness of solutions are proved. All possible equilibrium points of this system are investigated. The sufficient conditions of local stability of equilibrium points for the considered system are determined. Finally, numerical simulation results are carried out to confirm the theoretical results.