In this paper, by means of the invariance principle of differential equations, an adaptive feedback scheme is proposed to realize desynchronization in synchronous multi-coupled chaotic neurons by the mix-adaptive feedback effectively. Numerical simulations for the Hindmarsh-Rose neural model with self-coupling are illustrated which agree well with our theoretical analysis. It is observed that the feedback strengths asymptotically converge to a local fixed value in finite time, especially for linear coupling chaotic neurons with self-coupling. Furthermore, robustness of desynchronization in three coupled chaotic neurons on small mismatch of parameters is shown.