Dynamics of Clomethiazole Edisylate Interaction with Plastic Infusion Systems

Prediction of Solute Sorption by Polyvinyl Chloride Plastic Infusion Bags

“…17 The regression did not include the sorption data for clomethiazole, as this substance affects the properties of the plastic infusion bag. 16 From a practical standpoint, the ability of the method to predict solute loss, given the octanol-water partition coefficient of the solute is of interest. Table I1 shows a comparison of the observed results of Illum and Bundgaardlg and values predicted using eqs 9, 19, and 23.…”

Surface characterisation of bags for total parenteral nutrition by tensiometry and atomic force microscopy

“…A problem, associated with the use of these plastic bags, is the loss of solution components through adsorption on the inner surface of the container. This phenomenon has been reported to occur for several drugs, such as diazepam, insulin and organic nitrates for which significant losses have been noted after storage of perfusion liquid in TPN bags (Weisenfeld et al, 1968;Parker et al, 1979;Yuen et al, 1979;Roberts et al, 1980;Kowaluk et al, 1984), the adsorption of solution components being dependent on contact time and wettability of the polymers.…”

Percutaneous Absorption of Sunscreen Agents from Liquid Paraffin: Self-Association of Octyl Salicylate and Effects on Skin Flux

“…However, in choosing a suitable membrane for a defined drug it is important to be aware of potential interactions which may occur between the drug and the synthetic membrane. 10 Such interactions may influence membrane permeability and thereby render the membrane unsuitable as a model for isolating possibly altered skin permeability.…”