Dynamics of fluorine-18-fluorodeoxyglucose uptake in the liver and its correlation with hepatic fat content and BMI

Seraj, Siavash Mehdizadeh; Al-Zaghal, Abdullah; Zadeh, Mahdi Zirakchian; Jahangiri, Pegah; Pournazari, Kamyar; Raynor, William; Werner, Thomas; Høilund‐Carlsen, Poul Flemming; Alavi, Abass; Hunt, Stephen

doi:10.1097/mnm.0000000000001000

Cited by 4 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both FLI and HSI showed a significant direct correlation with BMI in both groups (Table 1 ). Fibrosis-4 (FIB-4) score (Seraj et al 2019 ) indicated fibrosis in (20/50) and 40% of fatty and non-fatty liver groups; respectively. Albumin level was available only for two patients in the fatty liver group and NAFLD fibrosis (NFS) score (Ahmed et al 2022 ) indicated F3-F4 (advanced/sever) fibrosis in both of the two patients.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The effect of hepatic steatosis on 18F-FDG uptake in PET-CT examinations of cancer Egyptian patients

Ali,

El-Abd,

Morsi

et al. 2023

European J Hybrid Imaging

View full text Add to dashboard Cite

Background Hepatic steatosis is the most common chronic hepatic disease. Imaging diagnosis of hepatic steatosis has been evaluated as an alternative to invasive histological diagnosis. Study aims The study aimed to assess the effect of hepatic steatosis on Flourine-18 fluorodeoxyglucose (18F-FDG) uptakes in cancer patients. Patients and Methods Blood samples were collected from 50 cancer patients and analyzed to calculate fatty liver index and Hepatic steatosis index (HIS). Hepatic steatosis examined using high-resolution ultrasound and positron emission tomography—computed tomography (PET-CT). Linear attenuation coefficient, standardized-uptake value (SUV) mean (SUV mean), and SUV maximum (SUVmax) were measured. Accordingly, patients were divided equally into non-fatty liver, and fatty liver groups. Results A significant increase in SUVmax and SUV mean was observed in the fatty liver group more than in the non-fatty liver group. HSI significantly increased in the fatty liver group compared to the non-fatty liver group. Liver tissue uptake FDG was significantly correlated with HSI values. SUV max significantly correlated with body mass index (BMI) in the non-fatty group only. Conclusion Hepatic changes in cancer patients affect the liver metabolic activity and thus the 18 F-FDG uptake. Therefore, further corrections should be considered when the liver is used as a comparator for PET-CT scans of cancer patients.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Several studies investigated the possible effect of fatty infiltration on liver SUVs (Abikhzer et al 2011 ; Kim et al 2011 ; Keramida et al 2014 ; Keramida et al 2014 ; Liu et al 2015 ; McDermott et al 2019 ; Rozenblum et al 2020 ; Seraj et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The effect of hepatic steatosis on 18F-FDG uptake in PET-CT examinations of cancer Egyptian patients

Ali,

El-Abd,

Morsi

et al. 2023

European J Hybrid Imaging

View full text Add to dashboard Cite

show abstract

“…At the same time, in the retrospective grouping study based on BMI values, the LPR and LPR20 in group A were significantly higher than those in group B, but there was no obvious difference between the two groups in terms of the LSR and LSR20. This may be related to the fact that the lava sequence used in this study was a fat suppression sequence and that the visceral fat fraction of the liver and spleen was positively correlated with BMI (20)(21)(22). In the ratio of hepatic parenchymal signal to splenic parenchymal signal, BMI exerted a similar effect on the liver and spleen, i.e., the higher the BMI, the higher the liver and spleen fat fraction, which was manifested by both the liver and spleen producing more signal loss on the lava sequence, their ratio might be relatively constant, and there was no change in the two groups of patients with different BMIs.…”

Section: Discussionmentioning

confidence: 99%

Effect of BMI on image contrast in the hepatobiliary phase of Gd-EOB-DTPA-enhanced-MRI and its clinical application: a comparative study

Chen¹,

Lu²,

Xiao³

et al. 2023

Ann Transl Med

View full text Add to dashboard Cite

Background: Gadolinium-ethoxybenzyl-diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) can detect more lesions through the image contrast of hepatobiliary phase. Body mass index (BMI) reflects the composition ratio of human tissue, which is an influencing factor of magnetic resonance image contrast. Meanwhile, Gd-EOB-DTPA is recommended to use the minimum dose when the diagnosis demands could be met. The aim of this paper was to investigate the effect of BMI on hepatobiliary phase image contrast and explore the feasibility of using low-dose Gd-EOB-DTPA to obtain good image contrast in hepatobiliary phase in patients with normal and lean BMI.Methods: Patients who had previously undergone Gd-EOB-DTPA-enhanced MRI (0.025 mmol/kg) were collected and divided into group A (BMI <24) and group B (BMI ≥24) according to Chinese BMI standards.Ratio of hepatic parenchymal signal to portal vein signal (LPR20) and hepatic parenchymal signal to splenic parenchymal signal (LSR20) in hepatobiliary phase (20 min after injection) were calculated. Patients with a BMI <24 who were about to receive Gd-EOB-DTPA-enhanced MRI were randomly divided into group C (0.0125 mmol/kg) and group D (0.025 mmol/kg). Image acquisition was performed at 10, 15, and 20 min after injection. LPR10, LPR15, LPR20 and LSR10, LSR15, LSR20 in corresponding phases were calculated.Results: In retrospective grouping study, compared with group B, group A's LPR20 was significantly higher [2.63 (2.42-3.00) vs. 2.22 (1.97-2.67); P<0.01]. In prospective grouping study, there were no differences in LPR15, LSR15, LPR20 and LSR20 between group C and group D. Intragroup comparison in each group showed that LPR15 (group C: 2.67±0.33; group D: 2.61±0.21) and LPR20 (group C: 2.74±0.37; group D: 2.72±0.27) were higher than LPR10 (group C: 2.19±0.18; group D: 1.94±0.17) (all P<0.01), while there were no changes between LPR15 and LPR20.Conclusions: Under conventional dose, hepatobiliary phase image contrast in patients with a BMI <24 was higher, which was mainly manifested in the high contrast between hepatic parenchyma and portal vein.For patients with a BMI <24, using a half conventional dose (0.0125 mmol/kg), good hepatobiliary phase image contrast can still be obtained at 15-20 min after administration, satisfying the diagnostic needs while also reducing the dosage of Gd-EOB-DTPA.

show abstract

The role of conventional and novel PET radiotracers in assessment of myeloma bone disease

Zirakchian Zadeh

2024

Bone

View full text Add to dashboard Cite

Dynamics of fluorine-18-fluorodeoxyglucose uptake in the liver and its correlation with hepatic fat content and BMI

Cited by 4 publications

References 30 publications

The effect of hepatic steatosis on 18F-FDG uptake in PET-CT examinations of cancer Egyptian patients

The effect of hepatic steatosis on 18F-FDG uptake in PET-CT examinations of cancer Egyptian patients

Effect of BMI on image contrast in the hepatobiliary phase of Gd-EOB-DTPA-enhanced-MRI and its clinical application: a comparative study

The role of conventional and novel PET radiotracers in assessment of myeloma bone disease

Contact Info

Product

Resources

About