We discuss the relevance of quantum gravity to the frontier questions in high energy phenomenology: the problems of dark matter, dark energy, and vacuum selection as well as the problems of emergent spacetime and wormholes. Dark matter and dark energy phenomenology, and the problem of vacuum selection are discussed within the context of string theory as a model of quantum gravity. Emergent spacetime and wormholes are discussed in a more general context of effective theories of quantum gravity.