Dynamics of Helicobacter pylori infection in a US–Mexico cohort during the first two years of life

Goodman, Karen J.; O’Rourke, Kathleen; Day, R S; Wang, Constance; Nurgalieva, Zhannat Z.; Phillips, Carl; Aragaki, Corinne; Campos, Armando; Rosa, Jose Manuel de la

doi:10.1093/ije/dyi152

Cited by 69 publications

(63 citation statements)

References 47 publications

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“…Because queens are fed from worker hypopharyngeal glands, and because beespecific alphaproteobacteria are heavily associated with this gland, our results suggest a model in which queen guts are colonized by bacteria from a specific worker organ. This result contrasts with routes of inoculation for mammalian microbiomes, where the maternal environment is the source of bacteria for the next generation (26)(27)(28).…”

mentioning

confidence: 89%

Development of the Honey Bee Gut Microbiome throughout the Queen-Rearing Process

Tarpy

Mattila

Newton

2015

Appl Environ Microbiol

122

109

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The European honey bee (Apis mellifera) is used extensively to produce hive products and for crop pollination, but pervasive concerns about colony health and population decline have sparked an interest in the microbial communities that are associated with these important insects. Currently, only the microbiome of workers has been characterized, while little to nothing is known about the bacterial communities that are associated with queens, even though their health and proper function are central to colony productivity. Here, we provide a large-scale analysis of the gut microbiome of honey bee queens during their developmental trajectory and through the multiple colonies that host them as part of modern queen-rearing practices. We found that queen microbiomes underwent a dramatic shift in size and composition as they aged and encountered different worker populations and colony environments. Queen microbiomes were dominated by enteric bacteria in early life but were comprised primarily of alphaproteobacteria at maturity. Furthermore, queen gut microbiomes did not reflect those of the workers who tended them and, indeed, they lacked many of the bacteria that are considered vital to workers. While worker gut microbiotas were consistent across the unrelated colony populations sampled, the microbiotas of the related queens were highly variable. Bacterial communities in mature queen guts were similar in size to those of mature workers and were characterized by dominant and specific alphaproteobacterial strains known to be associated with worker hypopharyngeal glands. Our results suggest a model in which queen guts are colonized by bacteria from workers' glands, in contrast to routes of maternal inoculation for other animal microbiomes.H oney bees (Apis spp.) are characterized by a highly partitioned reproductive division of labor, where a single queen lays the eggs that give rise to virtually all members of her colony, and her daughters, the workers, execute all other laborious jobs, including that of caring for her offspring (1). As the sole caregivers in the colony, workers share food extensively with one another, consuming their colony's food reserves and then distributing nutrients in various forms to their queen, other workers, and reproductive males (drones) (2). For all three of these castes, workers share food with adults through trophallaxis (mouth-to-mouth food transfer of liquids from one worker's gut to another's) or by feeding developing larvae brood food (glandular secretions derived from consumed nutrients). Because of these mechanisms of food distribution, a honey bee colony often is considered to have a "social stomach." Studies with tracers show rapid distribution (Ͻ24 h) of food from small numbers of individuals to many, if not the majority, of colony members across all ages and castes (3-7). Nurse-age bees (typically less than 10 days old) are the primary consumers of pollen (8); thus, they are the main distributors of pollen-based nutrients to adults and the brood that they rear (3, 5). Nectar als...

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mentioning

confidence: 89%

Development of the Honey Bee Gut Microbiome throughout the Queen-Rearing Process

Tarpy

Mattila

Newton

2015

Appl Environ Microbiol

122

109

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“…Similar findings were reported in Peru, which found an overall prevalence decreased from 71.4% to 47.9% when children were between 6 and 18 months of age (Klein et al, 1994). Thus, while H. pylori infections in children appears to have repeated cycles of acquiring and losing the infection until the infection eventually becomes chronic, in adults it is chronic (Goodman et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Non-invasive detection of Helicobacter pylori virulence genotypes ureA, vacA, cagA and babA2 among asymptomatic Egyptian infants

Enas¹,

Alkassem²,

Ashraf³

2014

Afr. J. Microbiol. Res.

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“…For example, crowded living conditions and high population density are associated with increased rates of microbial transmission, and similar conditions would be expected to increase intrafamilial spread. H. pylori acquisition, for example, is enhanced under such conditions (Cervantes et al 2010, Ford et al 2007, Goodman et al 2005, Goodman & Correa 2000, Nguyen et al 2006.…”

Section: Vertical and Horizontal Transmissionmentioning

confidence: 99%

“…Early colonization may be transient (Perez et al 2003) and multiple exposures may be necessary to establish persistent colonization (Goodman et al 2005). Under conditions of reduced hygiene, consistent with most of human history and prehistory, hosts often acquire multiple strains that establish in the stomach (Ghose et al 2005) and may compete for gastric niches or cooperate, at least in part, by the exchange of genetic material (Falush et al 2001, Lin et al 2009).…”

Section: Helicobacter Pylorimentioning

confidence: 99%

The Human Microbiota as a Marker for Migrations of Individuals and Populations

Domínguez-Bello

Blaser

2011

Annu. Rev. Anthropol.

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In this review, we discuss evidence that the microbes that constitute the human microbiota coevolved with humans and maintain complex community and host interactions. Because these microbes are mostly vertically transmitted, they have evolved within each human group and provide a view of human ancestry. In particular, we discuss using Helicobacter pylori as a marker of ancestry and migrations. Other organisms with more mixed vertical and horizontal transmission are not suitable to trace migrations with any fidelity. Human mixing affects microbial phylogeographic signals, and lifestyles impact the human microbiome population structure. A decade after the human genome was sequenced, we are gaining insights into the population structure of the human microbiome. We also examine whether, rather than focus on the genetics of single microbial populations, a wider approach to the study of human ancestry based on the human microbiome is now possible.

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Dynamics of Helicobacter pylori infection in a US–Mexico cohort during the first two years of life

Cited by 69 publications

References 47 publications

Development of the Honey Bee Gut Microbiome throughout the Queen-Rearing Process

Development of the Honey Bee Gut Microbiome throughout the Queen-Rearing Process

Non-invasive detection of Helicobacter pylori virulence genotypes ureA, vacA, cagA and babA2 among asymptomatic Egyptian infants

The Human Microbiota as a Marker for Migrations of Individuals and Populations

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